Nicotinic cholinergic systems are involved with several important aspects of cognitive
function including attention, learning and memory. Nicotinic cholinergic receptors are …

A major hurdle in defining the molecular biology of nicotine addiction has been
characterizing the different nicotinic acetylcholine receptor (nAChR) subtypes in the brain …

Agonists and positive allosteric modulators of the α7 nicotinic acetylcholine receptor
(nAChR) are currently being developed for the treatment of cognitive disturbances in …

Substantial evidence demonstrates both nicotine's addiction liability and its cognition-
enhancing effects. However, the neurobiological mechanisms underlying nicotine's impact …

This study establishes that presynaptic nicotinic receptors modulate dopamine release in the
mouse striatum. Nicotinic agonists elicit a dose‐dependent increase in the release of [3H] …

This review summarizes studies that attempted to determine the subtypes of nicotinic
acetylcholine receptors (nAChR) expressed in the dopaminergic nerve terminals in the …

While most cigarette smokers endorse a desire to quit smoking, only about 14% to 49% will
achieve abstinence after 6 months or more of treatment. A greater understanding of the …

Rapid decrement of response to repeated stimuli is a characteristic of hippocampal neurons.
To assess the possible role in this process of cholinergic afferents from the medial septal …

Accumulating evidence suggests that CNS α7 nicotinic acetylcholine receptors (nAChRs)
are important targets for the development of therapeutic approaches for Parkinson's disease …

Nicotine causes changes in brain nicotinic acetylcholine receptors (nAChRs) during
smoking that initiate addiction. Nicotine-induced upregulation is the long-lasting increase in …