Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …

The initiation and development of major inflammatory diseases, ie, cancer, vascular
inflammation, and some autoimmune diseases are closely linked to the immune system …

Mitochondria fuse and divide in response to cell demands and environment. Alterations in
mitochondrial dynamics underlie various human diseases, including cancer and neurologic …

Background Riociguat, a soluble guanylate cyclase stimulator, has been shown in a phase 2
trial to be beneficial in the treatment of pulmonary arterial hypertension. Methods In this …

Lysine acetylation is a conserved, reversible, post-translational protein modification
regulated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs; also known …

Pulmonary vascular remodeling is the key structural alteration in pulmonary hypertension
and involves changes in the intima, media and adventitia, often with the interplay of …

Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling associated
with obliteration of pulmonary arterioles and formation of plexiform lesions composed of …

Pulmonary hypertension (PH) is characterized by increased proliferation and apoptosis
resistance of pulmonary artery smooth muscle cells (PASMCs). Forkhead box O (FoxO) …

IL-6 is a multifunctional proinflammatory cytokine that is elevated in the serum of patients
with pulmonary arterial hypertension (PAH) and can predict the survival of patients with …