Targeting integrin pathways: mechanisms and advances in therapy
X Pang, X He, Z Qiu, H Zhang, R Xie, Z Liu… - … and Targeted Therapy, 2023 - nature.com
Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …
Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials
Y Shi, H Zhang, S Huang, L Yin, F Wang… - … and Targeted Therapy, 2022 - nature.com
Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …
association analyses and candidate gene approaches illustrate the multigenic complexity of …
[HTML][HTML] Biological drug and drug delivery-mediated immunotherapy
The initiation and development of major inflammatory diseases, ie, cancer, vascular
inflammation, and some autoimmune diseases are closely linked to the immune system …
inflammation, and some autoimmune diseases are closely linked to the immune system …
Mitochondrial dynamics—mitochondrial fission and fusion in human diseases
SL Archer - New England Journal of Medicine, 2013 - Mass Medical Soc
Mitochondria fuse and divide in response to cell demands and environment. Alterations in
mitochondrial dynamics underlie various human diseases, including cancer and neurologic …
mitochondrial dynamics underlie various human diseases, including cancer and neurologic …
Riociguat for the treatment of pulmonary arterial hypertension
HA Ghofrani, N Galiè, F Grimminger… - … England Journal of …, 2013 - Mass Medical Soc
Background Riociguat, a soluble guanylate cyclase stimulator, has been shown in a phase 2
trial to be beneficial in the treatment of pulmonary arterial hypertension. Methods In this …
trial to be beneficial in the treatment of pulmonary arterial hypertension. Methods In this …
Lysine acetyltransferases and lysine deacetylases as targets for cardiovascular disease
P Li, J Ge, H Li - Nature Reviews Cardiology, 2020 - nature.com
Lysine acetylation is a conserved, reversible, post-translational protein modification
regulated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs; also known …
regulated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs; also known …
Pulmonary vascular remodeling in pulmonary hypertension
RM Tuder - Cell and tissue research, 2017 - Springer
Pulmonary vascular remodeling is the key structural alteration in pulmonary hypertension
and involves changes in the intima, media and adventitia, often with the interplay of …
and involves changes in the intima, media and adventitia, often with the interplay of …
An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling associated
with obliteration of pulmonary arterioles and formation of plexiform lesions composed of …
with obliteration of pulmonary arterioles and formation of plexiform lesions composed of …
Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension
R Savai, HM Al-Tamari, D Sedding, B Kojonazarov… - Nature medicine, 2014 - nature.com
Pulmonary hypertension (PH) is characterized by increased proliferation and apoptosis
resistance of pulmonary artery smooth muscle cells (PASMCs). Forkhead box O (FoxO) …
resistance of pulmonary artery smooth muscle cells (PASMCs). Forkhead box O (FoxO) …
Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension
T Hashimoto-Kataoka, N Hosen… - Proceedings of the …, 2015 - National Acad Sciences
IL-6 is a multifunctional proinflammatory cytokine that is elevated in the serum of patients
with pulmonary arterial hypertension (PAH) and can predict the survival of patients with …
with pulmonary arterial hypertension (PAH) and can predict the survival of patients with …