Gut-associated lymphoid tissues (GALT) are the key antigen sampling and adaptive immune
inductive sites within the intestinal wall. Human GALT includes the multi-follicular Peyer's …

The intestinal mucosal barrier is composed of epithelial cells that are protected by an
overlying host-secreted mucous layer and functions as the first line of defence against …

Epithelial organoids, such as those derived from stem cells of the intestine, have great
potential for modelling tissue and disease biology,,–. However, the approaches that are …

The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here
we study the cellular composition and hierarchy of the mouse tracheal epithelium by single …

The balance between bacterial colonization and its containment in the intestine is
indispensable for the symbiotic relationship between humans and their bacteria. One …

Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors
have been implicated in IBD pathogenesis, including host genetics, immune dysregulation …

The intestine is a unique organ inhabited by a tremendous number of microorganisms.
Intestinal epithelial cells greatly contribute to the maintenance of the symbiotic relationship …

Intestinal microbiome dysbiosis has been consistently described in patients with IBD. In the
last decades, Escherichia coli, and the adherent-invasive E coli (AIEC) pathotype in …

The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …

Humoral immune responses at mucosal surfaces have historically focused on IgA. Growing
evidence highlights the complexity of IgA-inducing pathways and the functional impact of IgA …