Dysregulation of gap junction intercellular communication (GJIC) is recognized as one of the
key hallmarks for identifying non-genotoxic carcinogens (NGTxC). Currently, there is a …

Astrocytes represent the reticular part of the central nervous system; gap junctions formed by
connexins Cx43, Cx30-and Cx26 provide for homocellular astrocyte-astrocyte coupling …

The pathological process and mechanism of myocardial ischemia (MI) is very complicated,
and remains unclear. An integrated proteomic-metabolomics analysis was applied to …

In our body, all the cells are constantly sharing chemical and electrical information with other
cells. This intercellular communication allows them to respond in a concerted way to …

Humans are exposed to phthalates released from plastics, cosmetics, or food on a daily
basis. Phthalates have low acute liver toxicity, but their chronic exposures could induce …

Donepezil is a potent acetylcholinesterase inhibitor, largely used worldwide to alleviate
cognitive symptoms in Alzheimer's disease (AD). Beyond the widely described neuronal …

Donepezil (DPZ) is an acetylcholinesterase inhibitor used in Alzheimer's disease to restore
cognitive functions but is endowed with limited efficacy. Recent studies pointed out the …

Bioelectric signals possess the ability to robustly control and manipulate patterning during
embryogenesis and tissue-level regeneration. Endogenous local and global electric fields …

Renal cell carcinoma (RCC) bone metastatis progression is driven by crosstalk between
tumor cells and the bone microenvironment, which includes osteoblasts, osteoclasts, and …

Central nervous system disorders remain the leading causes of mortality and morbidity
worldwide, affecting more than 1 billion patients. This therapeutic area suffers from high …