Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress
immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing …

B cells play a central role in the immunopathogenesis of glomerulonephritides and
transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple …

Whereas a B cell–transcriptional profile has been recorded for operationally tolerant kidney
graft patients, the role that B cells have in this tolerance has not been reported. In this study …

Regulatory B cells (Bregs) suppress immune responses through the secretion of interleukin-
10 (IL-10). This immunomodulatory capacity holds therapeutic potential, yet a definitional …

Background B cells produce alloantibodies and activate alloreactive T cells, negatively
affecting kidney transplant survival. By contrast, regulatory B cells are associated with …

The interest in regulatory B cells (Bregs) began in the 1970s with the evidence that B cells
could downregulate the immune system by the production of “inhibitory” antibodies …

Recent cross-sectional studies suggest an important role for transitional B lymphocytes
(CD19+ CD24hiCD38hi) in promoting transplant tolerance, and protecting from late antibody …

While B cells are traditionally known for their roles in antibody production, antigen
presentation and cytokine production, recent studies have highlighted the existence of B …

We and others have previously described signatures of tolerance in kidney transplantation
showing the differential expression of B cell–related genes and the relative expansions of B …

We report here the long-term clinical and immunological results of four living-donor kidney
transplant patients given autologous bone marrow-derived mesenchymal stromal cells …