Aetiology of hypospadias: a systematic review of genes and environment

LFM Van der Zanden, I Van Rooij… - Human reproduction …, 2012 - academic.oup.com
BACKGROUND Hypospadias is a common congenital malformation of the male external
genitalia. Most cases have an unknown aetiology, which is probably a mix of monogenic …

Environmental and genetic contributors to hypospadias: a review of the epidemiologic evidence

SL Carmichael, GM Shaw… - Birth Defects Research …, 2012 - Wiley Online Library
This review evaluates current knowledge related to trends in the prevalence of hypospadias,
the association of hypospadias with endocrine‐disrupting exposures, and the potential …

Hypospadias prevalence and trends in international birth defect surveillance systems, 1980–2010

X Yu, N Nassar, P Mastroiacovo, M Canfield… - European urology, 2019 - Elsevier
Background Hypospadias is a common male birth defect that has shown widespread
variation in reported prevalence estimates. Many countries have reported increasing trends …

Prenatal environmental risk factors for genital malformations in a population of 1442 French male newborns: a nested case–control study

L Gaspari, F Paris, C Jandel, N Kalfa… - Human …, 2011 - academic.oup.com
BACKGROUND Over the past decades, an increasing trend in male external genital
malformations such as cryptorchidism and hypospadias has led to the suspicion that …

Maternal exposures to endocrine disrupting chemicals and hypospadias in offspring

F Giordano, A Abballe, E De Felip… - … Research Part A …, 2010 - Wiley Online Library
BACKGROUND Prenatal exposures to endocrine‐disrupting chemicals (EDCs) are
suspected risk factors in the etiology of hypospadias. The aim of this case‐control study was …

High prevalence of micropenis in 2710 male newborns from an intensive‐use pesticide area of Northeastern Brazil

L Gaspari, DR Sampaio, F Paris… - … journal of andrology, 2012 - Wiley Online Library
Exposure to endocrine‐disrupting chemicals (EDCs) has been suggested to contribute to
the increasing trends of external genital malformation in male newborns. In Northeastern …

Prevalence and possible causes of hypospadias

L Ságodi, Á Kiss, E Kiss-Tóth, L Barkai - Orvosi Hetilap, 2014 - akjournals.com
Hypospadias is the most common congenital malformation of the male external genitalia.
After the heart and circulatory system, it is the second most common developmental disorder …

Study of stillbirth and major congenital anomaly among newborns in the high-level natural radiation areas of Kerala, India

G Jaikrishan, KR Sudheer, VJ Andrews… - Journal of Community …, 2013 - Springer
Monitoring newborns for adverse outcomes like stillbirth and major congenital anomalies
(MCA) is being carried out in government hospitals since 1995 in and around high-level …

[HTML][HTML] Intrauterine growth restriction and congenital malformations: a retrospective epidemiological study

G Puccio, M Giuffré, M Piccione, E Piro… - Italian journal of …, 2013 - Springer
Background Intrauterine growth restriction (IUGR) and small for gestational age (SGA) birth
have been considered possible indicators of the presence of malformations. The aim of this …

Severe hypospadias and its association with maternal‐placental factors

F Huisma, M Thomas… - American Journal of …, 2013 - Wiley Online Library
The neonate born small for gestational age (SGA, birth weight< 10th centile) with severe
hypospadias, and without the presence of other malformations, is a presentation which …