Sleep spindles: mechanisms and functions

LMJ Fernandez, A Lüthi - Physiological reviews, 2020 - journals.physiology.org
Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the sleeping
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …

Reduced sleep spindles in schizophrenia: a treatable endophenotype that links risk genes to impaired cognition?

DS Manoach, JQ Pan, SM Purcell, R Stickgold - Biological psychiatry, 2016 - Elsevier
Although schizophrenia (SZ) is defined by waking phenomena, abnormal sleep is a
common feature. In particular, there is accumulating evidence of a sleep spindle deficit …

Characterizing sleep spindles in 11,630 individuals from the National Sleep Research Resource

SM Purcell, DS Manoach, C Demanuele… - Nature …, 2017 - nature.com
Sleep spindles are characteristic electroencephalogram (EEG) signatures of stage 2 non-
rapid eye movement sleep. Implicated in sleep regulation and cognitive functioning …

Individual differences in frequency and topography of slow and fast sleep spindles

R Cox, AC Schapiro, DS Manoach… - Frontiers in human …, 2017 - frontiersin.org
Sleep spindles are transient oscillatory waveforms that occur during non-rapid eye
movement (NREM) sleep across widespread cortical areas. In humans, spindles can be …

Sleep for cognitive enhancement

S Diekelmann - Frontiers in systems neuroscience, 2014 - frontiersin.org
Sleep is essential for effective cognitive functioning. Loosing even a few hours of sleep can
have detrimental effects on a wide variety of cognitive processes such as attention …

Form and function of sleep spindles across the lifespan

BC Clawson, J Durkin, SJ Aton - Neural plasticity, 2016 - Wiley Online Library
Since the advent of EEG recordings, sleep spindles have been identified as hallmarks of
non‐REM sleep. Despite a broad general understanding of mechanisms of spindle …

Current issues related to motor sequence learning in humans

J Doyon, E Gabitov, S Vahdat, O Lungu… - Current opinion in …, 2018 - Elsevier
Highlights•Behavioral determinants and neural correlates of motor sequence
learning.•Advances in methodological approaches and neuroimaging data analyses.•Motor …

Abnormal sleep spindles, memory consolidation, and schizophrenia

DS Manoach, R Stickgold - Annual review of clinical psychology, 2019 - annualreviews.org
There is overwhelming evidence that sleep is crucial for memory consolidation. Patients with
schizophrenia and their unaffected relatives have a specific deficit in sleep spindles, a …

Sleep is for forgetting

GR Poe - Journal of Neuroscience, 2017 - Soc Neuroscience
It is possible that one of the essential functions of sleep is to take out the garbage, as it were,
erasing and “forgetting” information built up throughout the day that would clutter the …

A systematic review of the nature and correlates of sleep disturbance in early psychosis

G Davies, G Haddock, AR Yung, LD Mulligan… - Sleep medicine …, 2017 - Elsevier
Sleep disturbances are common in people with a diagnosis of schizophrenia and have been
associated with increased symptom severity, neurocognitive deficits and reduced quality of …