Early stage gastric adenocarcinoma: clinical and molecular landscapes

Y Hirata, A Noorani, S Song, L Wang… - Nature Reviews Clinical …, 2023 - nature.com
Gastric adenocarcinoma, even when diagnosed at an early (localized) disease stage, poses
a major health-care burden with cure rates that remain unsatisfactorily low, particularly in …

The effects of ARID1A mutation in gastric cancer and its significance for treatment

S Lu, R Duan, L Cong, Y Song - Cancer Cell International, 2023 - Springer
Gastric cancer (GC) has emerged as a significant issue in public health all worldwide as a
result of its high mortality rate and dismal prognosis. AT-rich interactive domain 1 A …

Somatic ARID1A mutation stratifies patients with gastric cancer to PD-1 blockade and adjuvant chemotherapy

Y Gu, P Zhang, J Wang, C Lin, H Liu, H Li, H He… - Cancer Immunology …, 2023 - Springer
Background AT-rich interaction domain 1A (ARID1A) encodes a vital component of
switch/sucrose non-fermentable chromatin-remodeling complex. Given its association with …

A distinct clinicopathological feature and prognosis of young gastric cancer patients aged≤ 45 years old

Q Huang, X Zheng, Y Jiao, Y Lei, X Li, F Bi… - Frontiers in …, 2021 - frontiersin.org
Purpose The aim of this retrospective study was to probe into clinicopathological features
and prognosis of early-onset gastric cancer (EOGC) patients aged≤ 45 years old. Methods …

SPOP promotes cervical cancer progression by inducing the movement of PD-1 away from PD-L1 in spatial localization

J Wu, Y Wu, Q Guo, S Chen, S Wang, X Wu… - Journal of translational …, 2022 - Springer
Background Metastasis is a major obstacle in the treatment of cervical cancer (CC), and
SPOP-mediated regulatory effects are involved in metastasis. However, the mechanisms …

The global, regional, and national burden of stomach cancer among adolescents and young adults in 204 countries and territories, 1990–2019: A population-based …

Z Zhang, J Wang, N Song, L Shi, J Du - Frontiers in Public Health, 2023 - frontiersin.org
Background Stomach cancer is a significant health problem in many countries. But
healthcare needs of adolescents and young adults (AYAs) stomach cancer patients have …

Setd2 deficiency promotes gastric tumorigenesis through inhibiting the SIRT1/FOXO pathway

W Feng, C Ma, H Rao, W Zhang, C Liu, Y Xu, R Aji… - Cancer Letters, 2023 - Elsevier
Gastric cancer (GC) is the fifth most common cancer and the second leading cause of cancer
death globally. SETD2 is a histone methyltransferase catalyzing tri-methylation of H3K36 …

ARID1A Mutations in Gastric Cancer: A Review with Focus on Clinicopathological Features, Molecular Background and Diagnostic Interpretation

G Angelico, G Attanasio, L Colarossi, C Colarossi… - Cancers, 2024 - mdpi.com
Simple Summary ARID1A mutations are emerging as a prognostic and predictive factor in
gastric cancer. Recent studies suggest their potential role in predicting patient response to …

Different trends of gastric cancer in China, Japan, Republic of Korea and United States of America

F Zhao, D Yang, Y Lan, X Li - iScience, 2024 - cell.com
Gastric cancer exerts a significant healthcare burden worldwide and is highly geographically
heterogeneous. This study investigates the burden of gastric cancer in China from 1990 to …

Clinical outcome and molecular landscape of patients with ARID1A‐loss gastric cancer

M Sun, Y Gu, H Fang, F Shao, C Lin, H Zhang… - Cancer …, 2024 - Wiley Online Library
Chromatin remodelers are commonly altered in human cancer. The mutation of AT‐rich
interactive domain 1A (ARID1A) in gastric cancer (GC), a component of the SWI/SNF …