Principles of nanoparticle design for overcoming biological barriers to drug delivery
E Blanco, H Shen, M Ferrari - Nature biotechnology, 2015 - nature.com
Biological barriers to drug transport prevent successful accumulation of nanotherapeutics
specifically at diseased sites, limiting efficacious responses in disease processes ranging …
specifically at diseased sites, limiting efficacious responses in disease processes ranging …
Nanomaterials for cancer immunotherapy
Cancer immunotherapy is quickly growing to be the fourth most important cancer therapy,
after surgery, radiation therapy, and chemotherapy. Immunotherapy is the most promising …
after surgery, radiation therapy, and chemotherapy. Immunotherapy is the most promising …
Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing
Current drug-safety assays for hepatotoxicity rely on biomarkers with low predictive power.
The production of radical species, specifically reactive oxygen species (ROS) and reactive …
The production of radical species, specifically reactive oxygen species (ROS) and reactive …
Fluorescent imaging of reactive oxygen and nitrogen species associated with pathophysiological processes
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play their essential
roles in regulating biological events. Their aberrant behaviors are mostly associated with …
roles in regulating biological events. Their aberrant behaviors are mostly associated with …
Calcium-based biomaterials for diagnosis, treatment, and theranostics
Calcium-based (CaXs) biomaterials including calcium phosphates, calcium carbonates,
calcium silicate and calcium fluoride have been widely utilized in the biomedical field owing …
calcium silicate and calcium fluoride have been widely utilized in the biomedical field owing …
Lipid-based nanoparticle technologies for liver targeting
Liver diseases such as hepatitis, cirrhosis, and hepatocellular carcinoma are global health
problems accounting for approximately 800 million cases and over 2 million deaths per year …
problems accounting for approximately 800 million cases and over 2 million deaths per year …
Biomolecule-assisted green synthesis of nanostructured calcium phosphates and their biomedical applications
Calcium phosphates (CaPs) are ubiquitous in nature and vertebrate bones and teeth, and
have high biocompatibility and promising applications in various biomedical fields …
have high biocompatibility and promising applications in various biomedical fields …
Nuclear localization signal-tagged systems: Relevant nuclear import principles in the context of current therapeutic design
Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules
active in the nucleus and minimizing off-target effects.'Active'nuclear-directed transport and …
active in the nucleus and minimizing off-target effects.'Active'nuclear-directed transport and …
Acidification-Induced Structure Evolution of Lipid Nanoparticles Correlates with Their In Vitro Gene Transfections
Z Li, J Carter, L Santos, C Webster, CF van der Walle… - ACS …, 2023 - ACS Publications
The rational design of lipid nanoparticles (LNPs) for enhanced gene delivery remains
challenging because of incomplete knowledge of their formulation–structure relationship …
challenging because of incomplete knowledge of their formulation–structure relationship …
Triple‐targeting delivery of CRISPR/Cas9 to reduce the risk of cardiovascular diseases
L Zhang, L Wang, Y Xie, P Wang… - Angewandte Chemie …, 2019 - Wiley Online Library
A high level of low‐density lipoprotein cholesterol (LDL‐C) in the blood is a major risk factor
for coronary heart disease. Herein, we present a triple‐targeting strategy to generate a loss …
for coronary heart disease. Herein, we present a triple‐targeting strategy to generate a loss …