[HTML][HTML] Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease
I Beltran-Hortelano, V Alcolea, M Font… - Bioorganic & medicinal …, 2022 - Elsevier
Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …
Update on relevant trypanosome peptidases: Validated targets and future challenges
VE Alvarez, PA Iribarren, GT Niemirowicz… - Biochimica et Biophysica …, 2021 - Elsevier
Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas disease, and
Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, the agents of …
Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, the agents of …
Magnetic biochar‐supported ZrO2 as an efficient catalyst for one‐pot synthesis of 1′, 4′‐dihydro‐3 H, 3′ H‐spiro [furo [3, 4‐b] quinoline‐9, 2′‐quinoxaline]‐1, 3 …
SZ Zhang, LN Dong, LP Mo… - Applied Organometallic …, 2023 - Wiley Online Library
A novel ZrO2 supported on a magnetic biochar material (CoFe2O4/BC‐ZrO2) was
synthesized using a relatively simple route. The prepared CoFe2O4/BC‐ZrO2 was …
synthesized using a relatively simple route. The prepared CoFe2O4/BC‐ZrO2 was …
Thiosemicarbazone derivatives: Evaluation as cruzipain inhibitors and molecular modeling study of complexes with cruzain
G Jasinski, E Salas-Sarduy, D Vega, L Fabian… - Bioorganic & Medicinal …, 2022 - Elsevier
The development of cruzipain inhibitors represents one of the most attractive challenges in
the search for drugs for the treatment of Chagas disease. A recombinant form of this enzyme …
the search for drugs for the treatment of Chagas disease. A recombinant form of this enzyme …
[HTML][HTML] Anti-Trypanosoma cruzi Properties of Sesquiterpene Lactones Isolated from Stevia spp.: In Vitro and In Silico Studies
J Borgo, OG Elso, J Gomez, M Coll, CAN Catalán… - Pharmaceutics, 2023 - mdpi.com
Stevia species (Asteraceae) have been a rich source of terpenoid compounds, mainly
sesquiterpene lactones, several of which show antiprotozoal activity. In the search for new …
sesquiterpene lactones, several of which show antiprotozoal activity. In the search for new …
Coumarin-based derivatives targeting Trypanosoma cruzi cruzain and Trypanosoma brucei cathepsin L-like proteases
JA Nunes, FN da Silva, EB da Silva… - New Journal of …, 2023 - pubs.rsc.org
The protozoa, Trypanosoma cruzi (etiological agent of Chagas diseases–also named
American trypanosomiasis) and T. brucei (causative agent of human African …
American trypanosomiasis) and T. brucei (causative agent of human African …
Discovery and optimizing polycyclic pyridone compounds as anti-HBV agents
F Wei, D Kang, S Cherukupalli… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Hepatitis B disease is caused by the hepatitis B virus (HBV), which is a DNA
virus that belongs to the Hepadnaviridae family. It is a considerable health burden, with 257 …
virus that belongs to the Hepadnaviridae family. It is a considerable health burden, with 257 …
[PDF][PDF] Thirty Years in the Design and Development of Cruzain Inhibitors
G Jasinski, MF Martinic, AG Moglioni - J. Braz. Chem. Soc, 2024 - researchgate.net
Cruzipain is the principal protease of Trypanosoma cruzi, the etiological agent of Chagas
disease. Since its discovery in the 1980s and the resolution of the crystal structure of cruzain …
disease. Since its discovery in the 1980s and the resolution of the crystal structure of cruzain …
Synthesis of isoxazolylpyrrolones by three-component reaction of α-ketoglutaric acid or its diethyl ester with 3-amino-5-methylisoxazole and aromatic aldehydes
YI Sakhno, OV Radchenko, EA Muravyova… - Chemistry of …, 2021 - Springer
Synthesis of isoxazolylpyrrolones by three-component reaction of α-ketoglutaric acid or its
diethyl ester with 3-amino-5-methylisoxazole and aromatic aldehydes | Chemistry of …
diethyl ester with 3-amino-5-methylisoxazole and aromatic aldehydes | Chemistry of …
Planejamento racional de novas cumarinas como potenciais inibidores de cisteíno proteases do Trypanosoma cruzi e Trypanosoma brucei
JA Nunes - 2023 - repositorio.ufal.br
As doenças negligenciadas são responsáveis por causar morbidade e mortalidade em todo
o mundo, sendo prevalentes em países tropicais e subtropicais. Dentre essas …
o mundo, sendo prevalentes em países tropicais e subtropicais. Dentre essas …