Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …

Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer
cells which enables replicative immortality. In contrast, telomerase activity is silenced in most …

Telomerase maintains genome stability by extending the 3′ telomeric repeats at eukaryotic
chromosome ends, thereby counterbalancing progressive loss caused by incomplete …

It has been hypothesized that G-quadruplexes can sequester the 3′ end of the telomere
and prevent it from being extended by telomerase. Here we purify and characterize stable …

Simple Summary A link between telomere length and some age-related diseases has been
identified, including metabolic syndrome. So far, there is no mechanism to explain the origin …

Telomere synthesis in cancer cells and stem cells involves trafficking of telomerase to Cajal
bodies, and telomerase is thought to be recruited to telomeres through interactions with …

Telomerase is the ribonucleoprotein enzyme that catalyzes the extension of telomeric DNA
in eukaryotes. Recent work has begun to reveal key aspects of the assembly of the human …

Box C/D and box H/ACA snoRNAs are abundant non-coding RNAs that localize in the
nucleolus and mostly function as guides for nucleotide modifications. While a large pool of …

The importance of telomere function for human health is exemplified by a collection of
Mendelian disorders referred to as the telomere biology disorders (TBDs), telomeropathies …

A constellation of related genetic diseases are caused by defects in the telomere
maintenance machinery. These disorders, often referred to as telomeropathies, share …