Glucosinolates, isothiocyanates, and their role in the regulation of autophagy and cellular function

P Maycotte, M Illanes, DA Moreno - Phytochemistry Reviews, 2024 - Springer
Autophagy is a cellular degradation process important for the maintenance of cytoplasmic
integrity which can be upregulated in response to stress which is active in eukaryotic cells …

Inflammasomes Are Influenced by Epigenetic and Autophagy Mechanisms in Colorectal Cancer Signaling

G Műzes, F Sipos - International Journal of Molecular Sciences, 2024 - mdpi.com
Inflammasomes contribute to colorectal cancer signaling by primarily inducing inflammation
in the surrounding tumor microenvironment. Its role in inflammation is receiving increasing …

Comprehensive Proteomics Analysis Reveals Dynamic Phenotypes of Tumor-Associated Macrophages and Their Precursor Cells in Tumor Progression

Y Liu, D Liu, Y Liu, B Fu, S Ji, R Wang… - Journal of Proteome …, 2024 - ACS Publications
Tumor-associated macrophages (TAMs) are key regulators in tumor progression, but the
precise role of bone marrow-derived monocytes (Mons) as TAM precursors and their …

[HTML][HTML] Potential Human Health Benefits of Phaseolus vulgaris L. var Venanzio: Effects on Cancer Cell Growth and Inflammation

C Bernardi, G Cappellucci, G Baini, AM Aloisi, F Finetti… - Nutrients, 2024 - mdpi.com
It is widely recognized that foods, biodiversity, and human health are strongly
interconnected, and many efforts have been made to understand the nutraceutical value of …

Deficiency in epithelium RAD50 aggravates UC via IL-6-mediated JAK1/2-STAT3 signaling and promotes development of colitis-associated cancer in mice

J Zhang, Y Mengli, T Zhang, X Song… - Journal of Crohn's …, 2024 - academic.oup.com
Background Ulcerative colitis (UC) is one of the most important risk factors for developing
colitis-associated cancer (CAC). Persistent DNA damage increases CAC risk and has been …

Probiotic-derived extracellular vesicles alleviate AFB1-induced intestinal injury by modulating the gut microbiota and AHR activation

J Li, M Shi, Y Wang, J Liu, S Liu, W Kang, X Liu… - Journal of …, 2024 - Springer
Abstract Background Aflatoxin B1 (AFB1) is a mycotoxin that widely found in the
environment and mouldy foods. AFB1 initially targets the intestine, and AFB1-induced …

ISCAZIM: Integrated Statistical Correlation Analysis for Zero-Inflated Microbiome Data

Z Fan, J Lv, S Zhang, B Gu, C Wang, T Zhang - Heliyon, 2024 - cell.com
Microbiome-metabolome association analysis is critical to reveal the key pairs of gut
microbiota and metabolites for discovery of the microbial biomarkers in chronic diseases …

Uncovering novel mechanisms of chitinase-3-like protein 1 in driving inflammation-associated cancers

Y Fan, Y Meng, X Hu, J Liu, X Qin - Cancer Cell International, 2024 - Springer
Abstract Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that is induced and
regulated by multiple factors during inflammation in enteritis, pneumonia, asthma, arthritis …

Regulation of mitochondrial quality control of intestinal stem cells in homeostasis and diseases

X Lei, Z Xu, Y Huang, L Huang, J Lang… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: Intestinal stem cells (ISCs) are crucial for the continuous renewal and
regeneration of the small intestinal epithelium. ISC fate decisions are strictly controlled by …

Improvement of chlorpyrifos-induced cognitive impairment by mountain grape anthocyanins based on PI3K/Akt signaling pathway

R Zhu, X Tong, Y Du, J Liu, X Xu, Y He, L Wen… - Pesticide Biochemistry …, 2024 - Elsevier
The organophosphorus insecticide Chlorpyrifos (CPF) is widely used worldwide due to its
high effectiveness. However, when ingested through the mouth and nose, it can cause …