[HTML][HTML] Regulated cell death (RCD) in cancer: key pathways and targeted therapies
F Peng, M Liao, R Qin, S Zhu, C Peng, L Fu… - Signal transduction and …, 2022 - nature.com
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …
form of cell death that can be regulated by a variety of biomacromolecules, which is …
Recent development of gold (I) and gold (III) complexes as therapeutic agents for cancer diseases
Y Lu, X Ma, X Chang, Z Liang, L Lv, M Shan… - Chemical Society …, 2022 - pubs.rsc.org
Metal complexes have demonstrated significant antitumor activities and platinum complexes
are well established in the clinical application of cancer chemotherapy. However, the …
are well established in the clinical application of cancer chemotherapy. However, the …
Thioredoxin reductase inhibition for cancer therapy
R Gencheva, ESJ Arnér - Annual Review of Pharmacology and …, 2022 - annualreviews.org
The cytosolic selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1), and to some extent
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …
Thioredoxin signaling pathways in cancer
Significance: Thioredoxin (Trx) is a powerful antioxidant that reduces protein disulfides to
maintain redox stability in cells and is involved in regulating multiple redox-dependent …
maintain redox stability in cells and is involved in regulating multiple redox-dependent …
Oral Anticancer Heterobimetallic PtIV−AuI Complexes Show High In Vivo Activity and Low Toxicity
Abstract AuI‐carbene and PtIV− AuI‐carbene prodrugs display low to sub‐μM activity
against several cancer cell lines and overcome cisplatin (cisPt) resistance. Linking a cisPt …
against several cancer cell lines and overcome cisplatin (cisPt) resistance. Linking a cisPt …
Metal N-heterocyclic carbene complexes in medicinal chemistry
I Ott - Advances in Inorganic Chemistry, 2020 - Elsevier
Based on their strong σ-donor properties N-heterocyclic carbene (NHC) ligands can form
stable complexes with many transition metals. Numerous applications of metal NHC …
stable complexes with many transition metals. Numerous applications of metal NHC …
[HTML][HTML] Function and application of flavonoids in the breast cancer
MY Park, Y Kim, SE Ha, HH Kim, PB Bhosale… - International Journal of …, 2022 - mdpi.com
Breast cancer is one of the top causes of death, particularly among women, and it affects
many women. Cancer can also be caused by various factors, including acquiring genetic …
many women. Cancer can also be caused by various factors, including acquiring genetic …
A Multitarget Gold (I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells
JJ Zhang, MA Abu el Maaty… - Angewandte Chemie …, 2020 - Wiley Online Library
A novel alkynyl phosphane gold (I) complex (trimethylphosphane)(3‐(1, 3‐dimethylxanthine‐
7‐yl) prop‐1‐yn‐1‐yl) gold (I) 1 displayed mutiple biological activites including selective …
7‐yl) prop‐1‐yn‐1‐yl) gold (I) 1 displayed mutiple biological activites including selective …
Oxaliplatin-loaded nanoemulsion containing Teucrium polium L. essential oil induces apoptosis in Colon cancer cell lines through ROS-mediated pathway
WA Al-Otaibi, SM AlMotwaa - Drug Delivery, 2022 - Taylor & Francis
Oxaliplatin (Oxa)-associated adverse side effects have considerably limited the clinical use
of the drug in colon cancer therapy. Mutant p53 has diverse mutational profiles in colon …
of the drug in colon cancer therapy. Mutant p53 has diverse mutational profiles in colon …
[HTML][HTML] Synthetic miR-21 decoy circularized by tRNA splicing mechanism inhibited tumorigenesis in glioblastoma in vitro and in vivo models
Glioblastoma multiforme (GBM) is the deadliest primary central nervous system tumor.
miRNAs (miRs), a class of non-coding RNAs, are considered pivotal post-transcriptional …
miRNAs (miRs), a class of non-coding RNAs, are considered pivotal post-transcriptional …