The escalating social and economic burden of an aging world population has placed aging
research at center stage. The hallmarks of aging comprise diverse molecular mechanisms …

Extracellular vesicles (EVs) released by neural cells play an essential role in brain
homeostasis and the crosstalk between neural cells and the periphery. EVs are diverse …

Idiopathic Parkinson's disease is characterized by a progressive loss of dopaminergic
neurons, but the exact disease aetiology remains largely unknown. To date, Parkinson's …

Despite the capacity of chaperones and other homeostatic components to restore folding
equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer …

Modulation of endogenous cellular defense mechanisms represents an innovative approach
to therapeutic intervention in diseases causing chronic tissue damage, such as in …

Many neurodegenerative disorders are characterized by conformational changes in proteins
that result in misfolding, aggregation and intra-or extra-neuronal accumulation of amyloid …

Rapidly progressive Alzheimer's disease (rpAD) is a particularly aggressive form of
Alzheimer's disease, with a median survival time of 7–10 months after diagnosis. Why these …

Little is known about the immune performance and interactions of CNS microglia/
macrophages in glioma patients. We found that microglia/macrophages were the …

Among diseases whose cure is still far from being discovered, Alzheimer's disease (AD) has
been recognized as a crucial medical and social problem. A major issue in AD research is …

J. Neurochem.(2010) 114, 13–27. Abstract The responses of the brain to infection, ischemia
and trauma share remarkable similarities. These and other conditions of the CNS coordinate …