Preclinical and clinical trials of new treatment strategies targeting cancer stem cells in subtypes of breast cancer

N Landeros, I Castillo, R Pérez-Castro - Cells, 2023 - mdpi.com
Breast cancer (BC) can be classified into various histological subtypes, each associated with
different prognoses and treatment options, including surgery, radiation, chemotherapy, and …

Towards a New 3Rs Era in the construction of 3D cell culture models simulating tumor microenvironment

L Zhang, W Liao, S Chen, Y Chen, P Cheng… - Frontiers in …, 2023 - frontiersin.org
Three-dimensional cell culture technology (3DCC) sits between two-dimensional cell culture
(2DCC) and animal models and is widely used in oncology research. Compared to 2DCC …

Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target

A Groenewoud, J Yin, MC Gelmi, S Alsafadi… - Cell Death …, 2023 - nature.com
Uveal melanoma (UM) has a high risk to progress to metastatic disease with a median
survival of 3.9 months after metastases detection, as metastatic UM responds poorly to …

Automated classification of breast cancer cells using high-throughput holographic cytometry

CX Chen, HS Park, H Price, A Wax - Frontiers in Physics, 2021 - frontiersin.org
Holographic cytometry is an ultra-high throughput quantitative phase imaging modality that
is capable of extracting subcellular information from millions of cells flowing through parallel …

The in vitro effects of Romina strawberry extract on 3D uterine leiomyosarcoma cells

S Greco, P Pellegrino, F Giampieri, F Capocasa… - Nutrients, 2023 - mdpi.com
Leiomyosarcoma is an aggressive soft tissue sarcoma derived from the smooth muscle cells
of the uterus. We tested the effect of Romina strawberry extract treatment on three …

[HTML][HTML] Breast Cancer Stem Cells and Tumor Heterogeneity: Characteristics and Therapeutic Strategies

A Romaniuk-Drapała, E Totoń, M Taube, M Idzik… - Cancers, 2024 - mdpi.com
Simple Summary Breast cancer stem cells (BCSCs) are a small population of cells in breast
cancer tumors, playing a putative role in the cancer's progression. BCSC biomarkers are …

Cancer Stem Cells from Definition to Detection and Targeted Drugs

B Ruszkowska-Ciastek, K Kwiatkowska… - International Journal of …, 2024 - mdpi.com
Cancers remain the second leading cause of mortality in the world. Preclinical and clinical
studies point an important role of cancer/leukaemia stem cells (CSCs/LSCs) in the …

Mitochondrial DNA Mutations in Colorectal Cancer Stem Cells: Implications for Tumor Dynamics and Therapeutic Strategies

NK Shakhpazyan, LM Mikhaleva… - Current Medicinal …, 2024 - benthamdirect.com
This review offers an in-depth analysis of mitochondrial DNA (mtDNA) mutations in
colorectal cancer stem cells (CSCs), emphasizing their significant impact on tumor dynamics …

[HTML][HTML] Cancer Stem Cells in Oral Squamous Cell Carcinoma: A Narrative Review on Experimental Characteristics and Methodological Challenges

SK Acharya, S Shai, YF Choon, I Gunardi, FK Hartanto… - Biomedicines, 2024 - mdpi.com
Cancer stem cells (CSCs) represent a subpopulation of cancer cells that are believed to
initiate and drive cancer progression. In animal models, xenotransplanted CSCs have …

In Vitro Tumorigenic Assay: A Tumor Sphere Assay for Cancer Stem Cells

A Yehya, H Bahmad, W Abou-Kheir - Cancer Stem Cells: Methods and …, 2024 - Springer
Cancer stem cells (CSCs) represent a subpopulation of tumor cells that are thought to be
responsible for therapy resistance, recurrence, and metastasis through their capacity to self …