Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …

Protein folding is inherently error prone, especially in the endoplasmic reticulum (ER). Even
with an elaborate network of molecular chaperones and protein folding facilitators …

Mistakes are part of our world and constantly occurring. Due to transcriptional and
translational failures, genomic mutations or diverse stress conditions like oxidation or heat …

Protein folding in the endoplasmic reticulum (ER) is monitored by ER quality control (ERQC)
mechanisms. Proteins that pass ERQC criteria traffic to their final destinations through the …

The eukaryotic heat shock response is an ancient and highly conserved transcriptional
program that results in the immediate synthesis of a battery of cytoprotective genes in the …

Ubiquitination regulates nearly all cellular processes by coordinated activity of ubiquitin
writers (E1, E2, and E3 enzymes), erasers (deubiquitinating enzymes) and readers (proteins …

Dysfunction of protein quality control contributes to the cellular pathology of polyglutamine
(polyQ) expansion diseases and other neurodegenerative disorders associated with …

Translation of messenger RNAs lacking a stop codon results in the addition of a carboxy-
terminal poly-lysine tract to the nascent polypeptide, causing ribosome stalling. Non-stop …

The billions of proteins inside a eukaryotic cell are organized among dozens of sub-cellular
compartments, within which they are further organized into protein complexes. The …

The chaperone protein network controls both initial protein folding and subsequent
maintenance of proteins in the cell. Although the native structure of a protein is principally …