Pancreatic islet transplantation is a promising treatment option for individuals with type 1
diabetes; however, maintaining islet function after transplantation remains a large challenge …

Human allogeneic islet transplantation (ITx) is emerging as a promising treatment option for
qualified patients with type 1 diabetes. However, widespread clinical application of …

Islet transplantation is a feasible therapeutic alternative for metabolically labile patients with
type 1 diabetes. The primary therapeutic target is stable glycemic control and prevention of …

Clinical islet transplantation has the potential to cure type 1 diabetes. Despite recent
therapeutic success, it is still uncommon because transplanted islets are damaged by …

In addition to immunological and wound healing cell and platelet delivery, ion stasis and
nutrient supply, blood delivers oxygen to cells and tissues and removes metabolic wastes …

One of the main factors limiting potential uptake of pancreas transplantation, particularly in
the United Kingdom, is the shortage of grafts. There has therefore been a recent expansion …

Donation after circulatory death (DCD) donors are increasingly being used as a source of
pancreas allografts for vascularized organ and islet transplantation. We provide practice …

Improved preservation techniques have the potential to improve transplant outcomes by
better maintaining donor organ quality and by making more organs available for …

Background All human islets used in research and for the clinical treatment of diabetes are
subject to ischemic damage during pancreas procurement, preservation, and islet isolation …

Organ transplantation provides the best available therapy for a myriad of medical conditions,
including end‐stage renal disease, hepatic failure and type I diabetes mellitus. The current …