Radiosensitization with antimetabolites has improved clinical outcome for patients with solid
malignancies, especially cancers of the GI tract, cervix, and head and neck. Fluorouracil …

Objectives: The contribution of overexpressed microRNA-21 and-221 (miR-21 and miR-221)
to the malignant phenotype was determined by inhibiting these miRNAs using antisense …

Resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in
non small cell lung cancer (NSCLC) is mediated by two major mechanisms namely …

Receptor tyrosine kinases (RTK) are therapeutic targets for the treatment of malignancy.
However, tumor cells develop resistance to targeted therapies through the activation of …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor
prognosis. Gemcitabine, as a single agent or in combination therapy, remains the frontline …

The accumulation of soluble oligomeric amyloid-β peptide (oAβ) proceeds the formation of
senile plaques and contributes to synaptic and memory deficits in Alzheimer's disease (AD) …

Attempts to target mutant KRAS have been unsuccessful. Here, we report the identification of
Smad ubiquitination regulatory factor 2 (SMURF2) and UBCH5 as a critical E3: E2 complex …

One of the mechanisms of the antitumor activity of green tea (−)‐epigallocatechin‐3‐gallate
(EGCG) is associated with its effect on epidermal growth factor receptor (EGFR)‐mediated …

Caffeine has been reported to prevent hepatocarcinogenesis. We investigated the molecular
mechanisms by which caffeine inhibits the growth of hepatocellular carcinoma (HCC) cells …

Purpose: This study aimed to investigate the utility of honokiol, a naturally occurring
compound, in the treatment of head and neck squamous cell carcinoma (HNSCC) as well as …