Medication (drug) use in human pregnancy is prevalent. Determining fetal safety and
efficacy of drugs is logistically challenging. However, predicting (not measuring) fetal drug …

The biogenic monoamine serotonin (5-hydroxytryptamine, 5-HT) is a chemical messenger
widely distributed in the brain and various other organs. Its homeostasis is maintained by the …

l-Tryptophan is an essential amino acid and a precursor of several physiologically active
metabolites. In the placenta, the serotonin and kynurenine metabolic pathways of tryptophan …

Spontaneous preterm birth is a serious medical condition responsible for substantial
perinatal morbidity and mortality. Its phenotypic characteristics, preterm labor with intact …

Depression is a prevalent condition affecting up to 20% of pregnant women. Hence, more
than 10% are prescribed antidepressant drugs, mainly serotonin reuptake inhibitors (SSRIs) …

An estimated 1.3 million pregnant women were living with HIV in 2018. HIV infection is
associated with adverse pregnancy outcomes and all HIV-positive pregnant women …

Steroid hormones play a crucial role in supporting a successful pregnancy and ensuring
proper fetal development. The placenta is one of the principal tissues in steroid production …

Brain development requires appropriate regulation of serotonin (5-HT) signaling from
distinct tissue sources across embryogenesis. At the maternal-fetal interface, the placenta is …

Maternal use of antidepressants has increased throughout the last decades; selective
serotonin reuptake inhibitors (SSRI) are the most prescribed antidepressants. Despite the …

Selective serotonin reuptake inhibitors (SSRI) are the most common antidepressant used by
pregnant women; however, they have been associated with adverse pregnancy outcomes …