The role of serotonin in food intake has been studied for decades. Food intake is mainly
regulated by two brain circuitries:(i) the homeostatic circuitry, which matches energy intake …

All classes of drug that are prescribed to treat depression are associated with withdrawal
syndromes. SSRI withdrawal syndrome occurs often and can be severe, and might compel …

A single dose of the serotonin 2A receptor (5-HT2AR) agonist psilocybin can have long-
lasting beneficial effects on mood, personality, and potentially on mindfulness, but …

Adaptation of the brain to the presence of a drug predicts withdrawal on cessation. The
outcome of adaptation is often referred to as 'physical dependence'in pharmacology, as …

The hypothesis of chronically low brain serotonin levels as pathophysiologically linked to
impulsive aggression has been around for several decades. Whereas the theory was initially …

Although we understand how serotonin receptors function at the single-cell level, what role
different serotonin receptors play in regulating brain-wide activity and, in turn, human …

We now recognise that withdrawal symptoms from antidepressants are common, and can be
severe and long-lasting in some people. Many withdrawal symptoms overlap with symptoms …

In recent years there has been a considerable debate on antidepressant drugs. Continued
drug treatment with antidepressant medications may stimulate processes that run counter to …

Background Migraine is one of the most common and disabling of all medical conditions,
affecting 16% of the general population, causing huge socioeconomic costs globally …

Background: Protracted withdrawal syndrome (PWS) after stopping antidepressants
(frequently also referred to as post-acute withdrawal syndrome or PAWS) has been …