Malignant tumors are characterized by dysregulated growth control, overcoming of
replicative senescence, and metastasis formation. Current therapeutic regimens mostly exert …

Mesenchymal stem cells (MSCs) are typically enriched from bone marrow via isolation of the
plastic adherent, fibroblastoid cell fraction. However, plastic adherent cultures elaborated …

Abstract Objectives Mesenchymal stem cells (MSCs) are used clinically in tissue
engineering and regenerative medicine. The proliferation and osteogenic differentiation …

Bone regeneration can be enhanced or accelerated by the delivery of osteogenic signalling
factors or bone forming cells. These factors have commonly provided benefit when retained …

Systemically administered fibroblast growth factors (FGFs) show anabolic effects on bone
formation in animals, whereas in vitro cell culture studies have demonstrated that FGFs …

Bone augmentation via tissue engineering has generated significant interest. We
hypothesized that periosteum-derived cells could be used in place of bone marrow stromal …

Pluripotent embryonic stem (ES) cells have the capability to differentiate to various cell types
and may represent an alternative cell source for the treatment of cartilage defects. Here, we …

OBJECTIVE: Synovium-derived stem cells (SDSCs) have proven to be superior in cartilage
regeneration compared with other sources of mesenchymal stem cells. We hypothesized …

The growth of melanocytes, the pigment-producing cells of the skin, normally is restricted to
the epidermis. Transformed melanocytes, which have invaded the dermis, however, have …

The basic fibroblast growth factor (bFGF) plays a significant role in promoting the process of
bone repair, but bFGF cannot keep its biological activity stable under normal physiological …