The alkylation of ketones is taught at basic undergraduate level. In many cases this
transformation leads to the formation of a new stereogenic center. However, the apparent …

Stable isotopes such as 2H, 13C, and 15N have important applications in chemistry and
drug discovery. Late-stage incorporation of uncommon isotopes via isotopic exchange …

Carboxylic acids, amides, and esters are ubiquitous motifs in functional organic molecules.
However, the reactivities of these high oxidation state carbonyl compounds are far lower …

Asymmetric alkylation of enolates is one of the most direct and important reactions to
prepare α-chiral carbonyl compounds. Except for the classical methods that rely on the use …

A boron-catalyzed α-allylation of carboxylic acids with allylsulfones under blue LED
irradiation conditions is developed. We propose that photoexcitation of catalytically …

The carboxyl group (COOH) is an omnipresent functional group in organic molecules, and
its direct catalytic activation represents an attractive synthetic method. Herein, we describe …

Capitalizing on the late‐stage diversification of an essential 1, 3‐diene intermediate, we
describe herein a 9‐step enantioselective total synthesis of (+)‐hyperforin and (+) …

Lithium enolates derived from carboxylic acids are ubiquitous intermediates in organic
synthesis. Asymmetric transformations with these intermediates, a central goal of organic …

A biomimetic route to farnesyl pyrophosphate and dimethyl orsellinic acid (DMOA)‐derived
meroterpenoid scaffolds has yet to be reported despite great interest from the chemistry and …

Secondary metabolites isolated from bioactive extracts of natural sources iteratively pioneer
the research in drug discovery. Modern medicine is often inspired by bioactive natural …