With the avalanche of protein sequences generated in the post-genomic age, it is highly
desired to develop automated methods for efficiently identifying various attributes of …

Recent advance in large-scale genome se-quencing has generated a huge volume of pro-
tein sequences. In order to timely utilize the in-formation hidden in these newly discovered …

What are the physical limits to cell behavior? Often, the physical limitations can be
dominated by the proteome, the cell's complement of proteins. We combine known protein …

In eukaryotic cells a molecular chaperone network associates with translating ribosomes,
assisting the maturation of emerging nascent polypeptides. Hsp70 is perhaps the major …

Cells face a constant challenge as they produce new proteins. The newly synthesized
polypeptides must be folded properly to avoid aggregation. If proteins do misfold, they must …

Achieving efficient cotranslational folding of complex proteomes poses a challenge for
eukaryotic cells. Nascent polypeptides that emerge vectorially from the ribosome often …

Amyloid fibril deposits of the intrinsically disordered hIAPP peptide are found in 95% of type
II diabetes patients, and the aggregation of this peptide is suggested to induce apoptotic cell …

Synonymous rare codons are considered to be sub-optimal for gene expression because
they are translated more slowly than common codons. Yet surprisingly, many protein coding …

Protein folding is an important problem in structural biology with significant medical
implications, particularly for misfolding disorders like Alzheimer's disease. Solving the …

Maintenance of a properly folded proteome is critical for bacterial survival at notably different
growth temperatures. Understanding the molecular basis of thermoadaptation has …