Whereas the cerebral cortex has long been regarded by neuroscientists as the major locus
of cognitive function, the white matter of the brain is increasingly recognized as equally …

Myelination of axons in the nervous system of vertebrates enables fast, saltatory impulse
propagation, one of the best-understood concepts in neurophysiology. However, it took a …

Oligodendrocytes have been considered as a functionally homogeneous population in the
central nervous system (CNS). We performed single-cell RNA sequencing on 5072 cells of …

The hypothalamus is one of the most complex brain structures involved in homeostatic
regulation. Defining cell composition and identifying cell-type-specific transcriptional …

Ambient RNA contamination in single-cell and single-nuclei RNA sequencing (snRNA-seq)
is a significant problem, but its consequences are poorly understood. Here, we show that …

Recent reports have revealed that oligodendrocyte precursor cells (OPCs) are
heterogeneous. It remains unclear whether such heterogeneity reflects different subtypes of …

Infants born prematurely are at high risk to develop white matter injury (WMI), due to
exposure to hypoxic and/or inflammatory insults. Such perinatal insults negatively impact the …

Myelin degeneration occurs in neurodegenerative diseases and aging. In these conditions,
resident oligodendrocyte progenitor cells (OPCs) differentiate into oligodendrocytes that …

Oligodendrocyte precursor cells (OPCs) are not merely a transitory progenitor cell type, but
rather a distinct and heterogeneous population of glia with various functions in the …

Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …