Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated
their epithelial antiproliferative response and benefit from increased TGFβ expression and …

Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and
viral infections. They are 'first responders' that can spontaneously recognize abnormal cells …

Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by a poor
prognosis and high mortality rate. Genetic mutations and altered molecular pathways serve …

Metastasis is the most complex and deadly event. Tumor-stromal interface is a place where
invasion of tumor cells in the form of single-cell or collective migration occurs, with the latter …

Transforming growth factor beta (TGFβ) is a pleiotropic cytokine that plays a key role in both
physiologic and pathologic conditions, including cancer. Importantly, TGFβ can exhibit both …

Background We assessed the safety, efficacy, and pharmacokinetics of the transforming
growth factor beta (TGFβ) receptor inhibitor galunisertib co-administered with the anti …

The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved
cytokines whose signalling modulates cell fate decision-making across varying cellular …

Simple Summary Cancer-associated fibroblasts (CAFs) play an important contributory role in
the microenvironment of tumors. They originate from different cells, have multiple pro-and …

Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …