Successful cell division requires the precise and timely coordination of chromosomal,
cytoskeletal and membrane trafficking events. These processes are regulated by the …

Aurora kinase B (AURKB) is a mitotic serine/threonine protein kinase that belongs to the
aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC) …

Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player
in chromosome segregation. As part of a macromolecular complex known as the …

Abnormal chromosome content—also known as aneuploidy—is the most common
characteristic of human solid tumours. It has therefore been proposed that aneuploidy …

The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

Survivin, a member of the family of inhibitor of apoptosis proteins, functions as a key
regulator of mitosis and programmed cell death. Initially, survivin was described as an …

Aurora B is a component of the chromosomal passenger complex (CPC) required for correct
spindle-kinetochore attachments during chromosome segregation and for cytokinesis. The …

Mitosis and meiosis are remarkable processes during which cells undergo profound
changes in their structure and physiology. These events are orchestrated with a precision …

Cells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis (D-
mitosis), a fact that has useful clinical ramifications. However, this delay is seldom …

Epigenetic dysregulation is a prominent feature in cancer, as exemplified by frequent
mutations in chromatin regulators, including the MLL/KMT2 family of histone …