To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …

Covering: 1990 to 2015 The clerodane diterpenoids are a widespread class of secondary
metabolites and have been found in several hundreds of plant species from various families …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Abstract Background and Rationale The dynorphin/kappa opioid receptor (KOR) system has
been implicated as a critical component of the stress response. Stress-induced activation of …

Written for practitioners in the field, this critically acclaimed bestseller provides authoritative
information focused on the investigation of drug-related deaths and practical approaches to …

Endogenous opioids seem to play a critical role in the regulation of mood states. For
example, there is accumulating evidence that stimulation of κ-opioid receptors, upon which …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

Primary afferents are known to be inhibited by kappa opioid receptor (KOR) signaling.
However, the specific types of somatosensory neurons that express KOR remain unclear …

The real or perceived proximity to death often results in a non-ordinary state of
consciousness characterized by phenomenological features such as the perception of …

G protein–coupled receptors (GPCRs) are an evolutionarily conserved family of signaling
molecules comprising approximately 2% of the human genome; this receptor family remains …