Biochemical and mechanical regulation of actin dynamics
Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …
Actin dynamics in cell migration
Cell migration is an essential process, both in unicellular organisms such as amoeba and as
individual or collective motility in highly developed multicellular organisms like mammals. It …
individual or collective motility in highly developed multicellular organisms like mammals. It …
[HTML][HTML] Pay attention to membrane tension: Mechanobiology of the cell surface
E Sitarska, A Diz-Muñoz - Current opinion in cell biology, 2020 - Elsevier
The cell surface is a mechanobiological unit that encompasses the plasma membrane, its
interacting proteins, and the complex underlying cytoskeleton. Recently, attention has been …
interacting proteins, and the complex underlying cytoskeleton. Recently, attention has been …
A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks
Heterodimeric capping protein (CP/CapZ) is an essential factor for the assembly of branched
actin networks, which push against cellular membranes to drive a large variety of cellular …
actin networks, which push against cellular membranes to drive a large variety of cellular …
F-actin cytoskeleton network self-organization through competition and cooperation
RS Kadzik, KE Homa, DR Kovar - Annual review of cell and …, 2020 - annualreviews.org
Many fundamental cellular processes such as division, polarization, endocytosis, and
motility require the assembly, maintenance, and disassembly of filamentous actin (F-actin) …
motility require the assembly, maintenance, and disassembly of filamentous actin (F-actin) …
Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments
The release of inorganic phosphate (Pi) from actin filaments constitutes a key step in their
regulated turnover, which is fundamental to many cellular functions. The mechanisms …
regulated turnover, which is fundamental to many cellular functions. The mechanisms …
Principles of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis
Force generation by actin assembly shapes cellular membranes. An experimentally
constrained multiscale model shows that a minimal branched actin network is sufficient to …
constrained multiscale model shows that a minimal branched actin network is sufficient to …
Systematic nanoscale analysis of endocytosis links efficient vesicle formation to patterned actin nucleation
Clathrin-mediated endocytosis is an essential cellular function in all eukaryotes that is driven
by a self-assembled macromolecular machine of over 50 different proteins in tens to …
by a self-assembled macromolecular machine of over 50 different proteins in tens to …
New insights into the formation and the function of lamellipodia and ruffles in mesenchymal cell migration
M Innocenti - Cell Adhesion & Migration, 2018 - Taylor & Francis
Lamellipodia and ruffles are veil-shaped cell protrusions composed of a highly branched
actin filament meshwork assembled by the Arp2/3 complex. These structures not only …
actin filament meshwork assembled by the Arp2/3 complex. These structures not only …
From WRC to Arp2/3: Collective molecular mechanisms of branched actin network assembly
Branched actin networks have emerged as major force-generating structures driving the
protrusions in various distinct cell types and processes, ranging from lamellipodia operating …
protrusions in various distinct cell types and processes, ranging from lamellipodia operating …