The purpose of this comprehensive review is to describe various aspects of crisis of opioid
use in the United States. The obstacles that must be surmounted are primarily inappropriate …

As early as the 19th century, OIH was observed in patients receiving morphine for pain. It
was recognized that a potent analgesic such as morphine could actually result in an …

Opioids are the most potent drugs used to control severe pain. However, neuroadaptation
prevents opioids' ability to provide long-term analgesia and produces opposite effects, ie …

This review summarizes recent findings on peripheral mechanisms underlying the
generation and inhibition of pain. The focus is on events occurring in peripheral injured …

Opiates are utilized routinely and effectively as a short-term analgesic treatment for a variety
of acute pain conditions such as occur following trauma, and for patients with painful …

Placebo treatments and opiate drugs are thought to have common effects on the opioid
system and pain-related brain processes. This has created excitement about the potential for …

Objective To provide family physicians with a practical clinical summary of the Canadian
Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain, developed by …

Chronic pain is an international health issue of immense importance that is influenced by
both physical and psychological factors. Opioids are useful in treating chronic pain but have …

Background and Objective: Sacroiliac (SI) joint pain is a challenging condition characterized
by limited treatment options. Recently, numerous studies have reported excellent …

For 2 weeks following surgery, 55 patients with preexisting chronic pain (CP) reported daily
postoperative pain with movement and at rest. Of these, 30 CP patients used opioid …