The ischemia-induced death of cardiomyocytes results in scar formation and reduced
contractility of the ventricle. Several preclinical and clinical studies have supported the …

Multipotent mesenchymal stem cells (MSCs) represent a promising autologous source for
regenerative medicine. Because MSCs can be isolated from adult tissues, they represent an …

Background—Vascular calcification is associated with increased morbidity and mortality in
stage V chronic kidney disease, yet its early pathogenesis and initiating mechanisms in vivo …

Amyotrophic lateral sclerosis (ALS) is a lethal disease affecting motoneurons. In familial
ALS, patients bear mutations in the superoxide dismutase gene (SOD1). We transplanted …

Cellular therapy with adult stem cells appears as an opportunity for treatment of Parkinson's
disease. To validate this approach, we studied the effects of transplantation of rat adult bone …

Lineage-priming is a molecular model of stem cell (SC) differentiation in which proliferating
SCs express a subset of genes associated to the differentiation pathways to which they can …

Background Bone marrow (BM) has been recognized as the main source of mesenchymal
stromal cells (MSC); however, MSC have also been detected in umbilical cord blood (UCB) …

The infusion of a source of endothelial progenitors (EPCs) to limb ischemia (LB) patients has
been used to increase angiogenesis. Because the formation of new blood vessels involves …

OBJECTIVE: Angiogenesis involves the interplay of endothelial progenitor cells, pericytes,
growth factors, and cellular matrix components. The use of mesenchymal stem cells, which …

Msx2 is a homeodomain transcription factor first identified in craniofacial bone and human
femoral osteoblasts. We hypothesized that Msx2 might activate skeletal Wnt signaling …