Resistance to chemically different natural product anti-cancer drugs (multidrug resistance, or
MDR) results from decreased drug accumulation, resulting from expression of one or more …

ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …

Synonymous single-nucleotide polymorphisms (SNPs) do not produce altered coding
sequences, and therefore they are not expected to change the function of the protein in …

Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …

The calcineurin inhibitors ciclosporin (cyclosporine) and tacrolimus are immunosuppressant
drugs used for the prevention of organ rejection following transplantation. Both agents are …

The MDR1 (ABCB1) gene encodes a membrane-bound transporter that actively effluxes a
wide range of compounds from cells. The overexpression of MDR1 by multidrug-resistant …

Interindividual differences of drug response are an important cause of treatment failures and
adverse drug reactions. The identification of polymorphisms explaining distinct phenotypes …

The product of the ABCB1 gene, P-glycoprotein (PGP), is a transmembrane active efflux
pump for a variety of drugs. It is a putative mechanism of multidrug resistance in a range of …

Drug treatment of epilepsy is characterized by unpredictability of efficacy, adverse drug
reactions, and optimal doses in individual patients, which, at least in part, is a consequence …

The immunosuppressive drug tacrolimus, whose pharmacokinetic characteristics display
large interindividual variations, is a substrate for P-glycoprotein (P-gp), the product of the …