The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members)
has been implicated in cancer and other human diseases. However, in contrast to the direct …

The androgen receptor (AR), ligand-induced transcription factor, is expressed in primary
prostate cancer and in metastases. AR regulates multiple cellular events, proliferation …

Androgens, acting through the androgen receptor (AR), are responsible for the development
of the male phenotype during embryogenesis, the achievement of sexual maturation at …

The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer
metastasis, due to their essential roles in regulating cell division and actin cytoskeletal …

Introduction: Rho GTPases are master regulators of actomyosin structure and dynamics and
play pivotal roles in a variety of cellular processes including cell morphology, gene …

Vav proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases. They
control processes including T cell activation, phagocytosis, and migration of normal and …

Background Prostate cancer is initially dependent on androgens for survival and growth,
making hormonal therapy the cornerstone treatment for late-stage tumors. However, despite …

Vav proteins play roles as guanosine nucleotide exchange factors for Rho GTPases and
signaling adaptors downstream of protein tyrosine kinases. The recent sequencing of the …

Rho guanosine triphosphatases (GTPases) are a family of small proteins which function as
molecular switches in a variety of signaling pathways following stimulation of cell surface …

Androgen receptor (AR) is a key factor in regulation of growth and differentiation in normal
and malignant prostate. Endocrine therapies for prostate cancer include inhibition of …