MicroRNA schizophrenia: etiology, biomarkers and therapeutic targets

HC Zhang, Y Du, L Chen, ZQ Yuan, Y Cheng - … & Biobehavioral Reviews, 2023 - Elsevier
The three sets of symptoms associated with schizophrenia—positive, negative, and
cognitive—are burdensome and have serious effects on public health, which affects up to …

Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform

A Rai, H Fang, B Claridge, RJ Simpson… - Journal of …, 2021 - Wiley Online Library
The extracellular vesicle (EV) surface proteome (surfaceome) acts as a fundamental
signalling gateway by bridging intra‐and extracellular signalling networks, dictates EVs' …

Prenatal methamphetamine—impact on the mother and child—a review

FA Perez, S Blythe, T Wouldes, K McNamara… - …, 2022 - Wiley Online Library
Methamphetamine (MA) is the second most commonly used illicit drug in the world, after
cannabis. There are limited data on the outcomes of pregnant MA users but there is rapidly …

[HTML][HTML] Scalable generation of nanovesicles from human-induced pluripotent stem cells for cardiac repair

J Lozano, A Rai, JG Lees, H Fang, B Claridge… - International Journal of …, 2022 - mdpi.com
Extracellular vesicles (EVs) from stem cells have shown significant therapeutic potential to
repair injured cardiac tissues and regulate pathological fibrosis. However, scalable …

[HTML][HTML] The proteomic architecture of schizophrenia iPSC-derived cerebral organoids reveals alterations in GWAS and neuronal development factors

M Notaras, A Lodhi, H Fang, D Greening… - Translational …, 2021 - nature.com
Schizophrenia (Scz) is a brain disorder that has a typical onset in early adulthood but
otherwise maintains unknown disease origins. Unfortunately, little progress has been made …

Proteomic profiling of human uterine extracellular vesicles reveal dynamic regulation of key players of embryo implantation and fertility during menstrual cycle

A Rai, QH Poh, M Fatmous, H Fang, S Gurung… - …, 2021 - Wiley Online Library
Endometrial extracellular vesicles (EVs) are emerging as important players in reproductive
biology. However, how their proteome is regulated throughout the menstrual cycle is not …

Proteome characterisation of extracellular vesicles isolated from heart

B Claridge, A Rai, H Fang, A Matsumoto, J Luo… - …, 2021 - Wiley Online Library
Cardiac intercellular communication is critical for heart function and often dysregulated in
cardiovascular diseases. While cardiac extracellular vesicles (cEVs) are emerging …

[HTML][HTML] Endometrial small extracellular vesicles regulate human trophectodermal cell invasion by reprogramming the phosphoproteome landscape

M Fatmous, A Rai, QH Poh, LA Salamonsen… - Frontiers in Cell and …, 2022 - frontiersin.org
A series of cyclical events within the uterus are crucial for pregnancy establishment. These
include endometrial regeneration following menses, under the influence of estrogen …

[HTML][HTML] Analysis of Acute and Chronic Methamphetamine Treatment in Mice on Gdnf System Expression Reveals a Potential Mechanism of Schizophrenia …

L Casserly, DR Garton, A Montaño-Rodriguez… - Biomolecules, 2023 - mdpi.com
The increase in presynaptic striatal dopamine is the main dopaminergic abnormality in
schizophrenia (SCZ). SCZ is primarily treated by modulating the activity of monoamine …

Exosomes derived from the human primary colorectal cancer cell line SW480 orchestrate fibroblast‐led cancer invasion

A Rai, DW Greening, R Xu, W Suwakulsiri… - …, 2020 - Wiley Online Library
In localized tumors, basement membrane (BM) prevents invasive outgrowth of tumor cells
into surrounding tissues. When carcinomas become invasive, cancer cells either degrade …