Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit
symptoms of increased anxiety, depression and cognitive impairment. Such patients need …

Neglected tropical diseases represent a major sanitary problem and a huge economic
burden to endemic countries, and are currently expanding to non-endemic countries owing …

The antinociceptive effects of the novel phentylethylamine antidepressant drug venlafaxine
and its interaction with various opioid, noradrenaline and serotonin receptor subtypes were …

Abstract Tramadol (Ultram, Ultracet) is a centrally acting synthetic opioid with analgesic
efficacy comparable to codeine. Antinociception is attributed to low but effective affinity for …

The antinociceptive effects of the noradrenergic and specific serotonergic antidepressant
(NaSSA) drug mirtazapine and its interaction with various opioid receptor subtypes were …

Using the mouse tail-flick assay, we evaluated the antinociceptive effect and the interaction
with the opioid, adrenergic, and serotonergic systems of the two “atypical” neuroleptic …

About 30% of major depression disorder patients fail to achieve remission, hence being
diagnosed with treatment-resistant major depression (TRD). Opium had been largely used …

This study used various experimental pain methods to investigate the effects of subacute
mianserin administration on diabetes-induced neuropathic pain in rats. The effect of …

BACKGROUND AND PURPOSE Antidepressants are known to interact with the opioid
system through mechanisms not completely understood. We previously reported that tricyclic …

The antinociceptive effects of trazodone (a triazolopyridine derivative with antidepressant
activity) and its interaction with various opioid, noradrenaline and serotonin receptor …