The ST2/IL-33 axis in immune cells during inflammatory diseases
B Griesenauer, S Paczesny - Frontiers in immunology, 2017 - frontiersin.org
Il1rl1 (also known as ST2) is a member of the IL-1 superfamily, and its only known ligand is
IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a …
IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a …
HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins
D Bertheloot, E Latz - Cellular & molecular immunology, 2017 - nature.com
Our immune system is based on the close collaboration of the innate and adaptive immune
systems for the rapid detection of any threats to the host. Recognition of pathogen-derived …
systems for the rapid detection of any threats to the host. Recognition of pathogen-derived …
The IL-1 family: regulators of immunity
JE Sims, DE Smith - Nature Reviews Immunology, 2010 - nature.com
Over recent years it has become increasingly clear that innate immune responses can
shape the adaptive immune response. Among the most potent molecules of the innate …
shape the adaptive immune response. Among the most potent molecules of the innate …
Elevated expression of IL-33 and TSLP in the airways of human asthmatics in vivo: a potential biomarker of severe refractory disease
Y Li, W Wang, Z Lv, Y Li, Y Chen, K Huang… - The Journal of …, 2018 - journals.aai.org
The epithelial cytokines IL-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been
implicated in asthma pathogenesis because they promote Th2-type cytokine synthesis, but …
implicated in asthma pathogenesis because they promote Th2-type cytokine synthesis, but …
Disease-associated functions of IL-33: the new kid in the IL-1 family
FY Liew, NI Pitman, IB McInnes - Nature Reviews Immunology, 2010 - nature.com
Abstract Interleukin-33 (IL-33), a newly described member of the IL-1 family, is expressed by
many cell types following pro-inflammatory stimulation and is thought to be released on cell …
many cell types following pro-inflammatory stimulation and is thought to be released on cell …
Pulmonary innate lymphoid cells are major producers of IL‐5 and IL‐13 in murine models of allergic asthma
RGJK Wolterink, A KleinJan… - European journal of …, 2012 - Wiley Online Library
Allergic asthma is characterized by chronic airway inflammation and hyperreactivity and is
thought to be mediated by an adaptive T helper‐2 (T h2) cell‐type immune resp‐onse. Here …
thought to be mediated by an adaptive T helper‐2 (T h2) cell‐type immune resp‐onse. Here …
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation
M Kurowska-Stolarska, B Stolarski, P Kewin… - The Journal of …, 2009 - journals.aai.org
Alternatively activated macrophages (AAM) play a crucial role in type 2 immunity. Mice
deficient in ST2, a receptor for the latest member of the IL-1 family, IL-33, have impaired type …
deficient in ST2, a receptor for the latest member of the IL-1 family, IL-33, have impaired type …
The many paths to asthma: phenotype shaped by innate and adaptive immunity
HY Kim, RH DeKruyff, DT Umetsu - Nature immunology, 2010 - nature.com
Asthma is a very complex and heterogeneous disease that is characterized by airway
inflammation and airway hyper-reactivity (AHR). The pathogenesis of asthma is associated …
inflammation and airway hyper-reactivity (AHR). The pathogenesis of asthma is associated …
Role of IL-17 in asthma pathogenesis and its implications for the clinic
RK Ramakrishnan, S Al Heialy… - Expert review of …, 2019 - Taylor & Francis
Introduction: Asthma is a respiratory disorder typically characterized by T-helper type 2 (Th2)
inflammation that is mediated by cytokines, including IL-4, IL-5, and IL-13 …
inflammation that is mediated by cytokines, including IL-4, IL-5, and IL-13 …
Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease
Chronic obstructive lung disease is characterized by persistent abnormalities in epithelial
and immune cell function that are driven, at least in part, by infection. Analysis of …
and immune cell function that are driven, at least in part, by infection. Analysis of …