Natural metalloproteins perform many functions—ranging from sensing to electron transfer
and catalysis—in which the position and property of each ligand and metal are dictated by …

Proteins are molecular machines whose function depends on their ability to achieve
complex folds with precisely defined structural and dynamic properties. The rational design …

Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

Influenza hemagglutinin (HA) is the primary target of the humoral response during
infection/vaccination. Current influenza vaccines typically fail to elicit/boost broadly …

The HIV-1 gp41 envelope glycoprotein promotes fusion of the virus and cell membranes
through the formation of a trimer-of-hairpins structure, in which the amino-and carboxyl …

Purpose: Tumor necrosis factor-related apoptosis–inducing ligand (TRAIL/Apo2L) exhibits
potent antitumor activity on systemic administration in nonhuman primates without …

Linear peptides derived from the HIV gp41 C-terminus (C-peptides), such as the 36-residue
Fuzeon, are potent HIV fusion inhibitors. These molecules bind to the N-peptide region of …

HIV envelope glycoprotein transmembrane subunit gp41 plays a critical role in the fusion
between viral and target cell membranes. Upon gp120 binding to CD4 and a coreceptor …

Metals are commonly found as natural constituents of proteins. Since many such metals can
interact specifically with their corresponding unfolded proteins in vitro, cofactor-binding prior …

Background aims Mesenchymal stromal cell (MSC) delivery of pro-apoptotic tumor necrosis
factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an attractive strategy for anticancer …