De novo metalloprotein design

MJ Chalkley, SI Mann, WF DeGrado - Nature Reviews Chemistry, 2022 - nature.com
Natural metalloproteins perform many functions—ranging from sensing to electron transfer
and catalysis—in which the position and property of each ligand and metal are dictated by …

De novo protein design, a retrospective

IV Korendovych, WF DeGrado - Quarterly reviews of biophysics, 2020 - cambridge.org
Proteins are molecular machines whose function depends on their ability to achieve
complex folds with precisely defined structural and dynamic properties. The rational design …

Protein design: toward functional metalloenzymes

F Yu, VM Cangelosi, ML Zastrow, M Tegoni… - Chemical …, 2014 - ACS Publications
Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection

VVA Mallajosyula, M Citron, F Ferrara… - Proceedings of the …, 2014 - National Acad Sciences
Influenza hemagglutinin (HA) is the primary target of the humoral response during
infection/vaccination. Current influenza vaccines typically fail to elicit/boost broadly …

Design of potent inhibitors of HIV-1 entry from the gp41 N-peptide region

DM Eckert, PS Kim - … of the National Academy of Sciences, 2001 - National Acad Sciences
The HIV-1 gp41 envelope glycoprotein promotes fusion of the virus and cell membranes
through the formation of a trimer-of-hairpins structure, in which the amino-and carboxyl …

Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs

TM Ganten, R Koschny, J Sykora… - Clinical cancer …, 2006 - AACR
Purpose: Tumor necrosis factor-related apoptosis–inducing ligand (TRAIL/Apo2L) exhibits
potent antitumor activity on systemic administration in nonhuman primates without …

Inhibiting HIV fusion with a β-peptide foldamer

OM Stephens, S Kim, BD Welch… - Journal of the …, 2005 - ACS Publications
Linear peptides derived from the HIV gp41 C-terminus (C-peptides), such as the 36-residue
Fuzeon, are potent HIV fusion inhibitors. These molecules bind to the N-peptide region of …

HIV entry inhibitors targeting gp41: from polypeptides to small-molecule compounds

S Liu, S Wu, S Jiang - Current pharmaceutical design, 2007 - ingentaconnect.com
HIV envelope glycoprotein transmembrane subunit gp41 plays a critical role in the fusion
between viral and target cell membranes. Upon gp120 binding to CD4 and a coreceptor …

Role of cofactors in metalloprotein folding

CJ Wilson, D Apiyo… - Quarterly reviews of …, 2004 - cambridge.org
Metals are commonly found as natural constituents of proteins. Since many such metals can
interact specifically with their corresponding unfolded proteins in vitro, cofactor-binding prior …

[HTML][HTML] Mesenchymal stromal cell delivery of full-length tumor necrosis factor–related apoptosis-inducing ligand is superior to soluble type for cancer therapy

ZQ Yuan, KK Kolluri, EK Sage, KHC Gowers, SM Janes - Cytotherapy, 2015 - Elsevier
Background aims Mesenchymal stromal cell (MSC) delivery of pro-apoptotic tumor necrosis
factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an attractive strategy for anticancer …