Generation of reactive oxygen species and related oxidants is an inevitable consequence of
life. Proteins are major targets for oxidation reactions, because of their rapid reaction rates …

This study aims to systematically review and meta-analyze the nitro-oxidative stress
(O&NS)/antioxidant (ANTIOX) ratio in the peripheral blood of people with mild cognitive …

Significance: Glutathione (GSH) represents the most abundant and the main antioxidant in
the body with important functions in the brain related to Alzheimer's disease (AD). Recent …

Apolipoprotein D is a chordate gene early originated in the Lipocalin protein family. Among
other features, regulation of its expression in a wide variety of disease conditions in humans …

Alzheimer's disease (AD) is one of the life-threatening neurodegenerative disorders in the
elderly (> 60 years) and incurable across the globe to date. AD is caused by the involvement …

The mitochondrial respiratory chain is the main site of reactive oxygen species (ROS)
production in the cell. Although mitochondria possess a powerful antioxidant system, an …

Vitamin D exerts a role in the maintenance of cognitive abilities and in frailty. Although
several studies evaluated the interactions between vitamin D and cognitive impairment …

Alzheimer's disease (AD) is the most common form of dementia and aging is the most
common risk factor for developing the disease. The etiology of AD is not known but AD may …

Oxidative stress plays an essential and early role in the pathophysiology of Alzheimer's
disease (AD). Alterations in the redox state in AD and in mild cognitive impairment (MCI) …

Background: Both advanced glycation end products (AGEs) N-(1-carboxymethyl)-L-lysine
(CML) and pentosidine were found in the brain from Alzheimer's disease (AD) patients and …