[HTML][HTML] The evolving pharmacotherapeutic landscape for the treatment of sickle cell disease
SK Ballas - Mediterranean Journal of Hematology and Infectious …, 2020 - ncbi.nlm.nih.gov
Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated
with global morbidity and early mortality. More effective and inexpensive therapies are …
with global morbidity and early mortality. More effective and inexpensive therapies are …
Oxidative stress in sickle cell disease: an overview of erythrocyte redox metabolism and current antioxidant therapeutic strategies
Erythrocytes have an environment of continuous pro-oxidant generation due to the presence
of hemoglobin (Hb), which represents an additional and quantitatively significant source of …
of hemoglobin (Hb), which represents an additional and quantitatively significant source of …
[HTML][HTML] Gum Arabic as novel anti-oxidant agent in sickle cell anemia, phase II trial
L Kaddam, I Fadl-Elmula, OA Eisawi, HA Abdelrazig… - BMC hematology, 2017 - Springer
Background Sickle cell anemia patients suffer from oxidative stress due to chronic
inflammation and self-oxidation of sickle hemoglobin (Hb S). Chronic oxidative stress …
inflammation and self-oxidation of sickle hemoglobin (Hb S). Chronic oxidative stress …
Hydroxyurea therapy modulates sickle cell anemia red blood cell physiology: Impact on RBC deformability, oxidative stress, nitrite levels and nitric oxide synthase …
E Nader, M Grau, R Fort, B Collins, G Cannas… - Nitric Oxide, 2018 - Elsevier
Hydroxyurea (HU) has been suggested to act as a nitric oxide (NO) donor in sickle cell
anemia (SCA). However, little is known about the HU NO-related effects on red blood cell …
anemia (SCA). However, little is known about the HU NO-related effects on red blood cell …
Sickle cell disease in the new era: advances in drug treatment
MT Lee, UO Ogu - Transfusion and Apheresis Science, 2022 - Elsevier
Sickle cell disease is an inherited blood disorder afflicting an estimated 100,000 individuals
in the United States and over 20 million people worldwide. The disease is heralded as the …
in the United States and over 20 million people worldwide. The disease is heralded as the …
[HTML][HTML] Hemoglobin oxidation–dependent reactions promote interactions with band 3 and oxidative changes in sickle cell–derived microparticles
S Jana, MB Strader, F Meng, W Hicks, T Kassa… - JCI insight, 2018 - ncbi.nlm.nih.gov
The contribution of intracellular hemoglobin (Hb) oxidation to RBC-derived microparticle
(MP) formation is poorly defined in sickle cell disease (SCD). Here we report that sickle Hb …
(MP) formation is poorly defined in sickle cell disease (SCD). Here we report that sickle Hb …
Effect of hydroxyurea treatment on the inflammatory markers among children with sickle cell disease
Background: Neutrophil-to-lymphocyte ratio (NLR) was introduced as a potential
inflammatory marker in sickle cell disease (SCD). This study aimed to evaluate the impact of …
inflammatory marker in sickle cell disease (SCD). This study aimed to evaluate the impact of …
Decoding the role of SOD2 in sickle cell disease
AM Dosunmu-Ogunbi, KC Wood, EM Novelli… - Blood …, 2019 - ashpublications.org
Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a single point
mutation in the β-globin gene. As a consequence, deoxygenated hemoglobin polymerizes …
mutation in the β-globin gene. As a consequence, deoxygenated hemoglobin polymerizes …
Risk of avascular necrosis of the femoral head in children with sickle cell disease on hydroxyurea: MRI evaluation
AD Adekile, R Gupta, A Al‐Khayat… - Pediatric blood & …, 2019 - Wiley Online Library
Background There are conflicting reports on the role of hydroxyurea (HU) in the
pathogenesis of avascular necrosis of the femoral head (AVNFH) in patients with sickle cell …
pathogenesis of avascular necrosis of the femoral head (AVNFH) in patients with sickle cell …
[HTML][HTML] Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and …
SCMA Yahouédéhou, CC da Guarda, CVB Figueiredo… - PloS one, 2019 - journals.plos.org
This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and
inflammatory parameters in children with sickle cell anemia (SCA) in association with βS …
inflammatory parameters in children with sickle cell anemia (SCA) in association with βS …