Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens
that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in …

Type I interferons (IFNs) play a crucial role in the innate immune avant-garde against viral
infections. Virtually all viruses have developed means to counteract the induction, signaling …

Diverse eukaryotic hosts produce virus-derived small interfering RNAs (siRNAs) to direct
antiviral immunity by RNA interference (RNAi). However, it remains unknown whether the …

Background We previously showed that small interfering RNAs (siRNAs) targeting the Zaire
Ebola virus (ZEBOV) RNA polymerase L protein formulated in stable nucleic acid-lipid …

Vertebrate genomes contain numerous copies of retroviral sequences, acquired over the
course of evolution. Until recently they were thought to be the only type of RNA viruses to be …

Ebola virus (EBOV) infection often results in fatal illness in humans, yet little is known about
how EBOV usurps host pathways during infection. To address this, we used affinity tag …

The cytoplasmic pattern recognition receptor RIG-I is activated by viral RNA and induces
type I IFN responses to control viral replication. The cellular dsRNA binding protein PACT …

Influenza A virus (IAV) causes annual epidemics and occasional pandemics, and is one of
the best-characterized human RNA viral pathogens 1. However, a physiologically relevant …

The filoviruses—Ebola virus and Marburg virus—cause lethal haemorrhagic fever in
humans and non-human primates (NHPs). Filoviruses present a global health threat both as …

Here, we show that the US Food and Drug Administration-approved oral drug nitazoxanide
(NTZ) broadly amplifies the host innate immune response to viruses and inhibits Ebola virus …