Clinical actionability of molecular targets in endometrial cancer
ME Urick, DW Bell - Nature Reviews Cancer, 2019 - nature.com
Abstract Endometrial cancer accounts for~ 76,000 deaths among women each year
worldwide. Disease mortality and the increasing number of new diagnoses make …
worldwide. Disease mortality and the increasing number of new diagnoses make …
Classification of endometrial carcinoma: more than two types
R Murali, RA Soslow, B Weigelt - The Lancet Oncology, 2014 - thelancet.com
Endometrial cancer is the most common gynaecological malignancy in Europe and North
America. Traditional classification of endometrial carcinoma is based either on clinical and …
America. Traditional classification of endometrial carcinoma is based either on clinical and …
Interpretation of somatic POLE mutations in endometrial carcinoma
A León‐Castillo, H Britton… - The Journal of …, 2020 - Wiley Online Library
Pathogenic somatic missense mutations within the DNA polymerase epsilon (POLE)
exonuclease domain define the important subtype of ultramutated tumours ('POLE …
exonuclease domain define the important subtype of ultramutated tumours ('POLE …
Randomized phase II trial of carboplatin-paclitaxel versus carboplatin-paclitaxel-trastuzumab in uterine serous carcinomas that overexpress human epidermal growth …
Purpose Uterine serous carcinoma is a rare, aggressive variant of endometrial cancer.
Trastuzumab is a humanized monoclonal antibody that targets human epidermal growth …
Trastuzumab is a humanized monoclonal antibody that targets human epidermal growth …
Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic …
F Skoulidis, LA Byers, L Diao, VA Papadimitrakopoulou… - Cancer discovery, 2015 - AACR
The molecular underpinnings that drive the heterogeneity of KRAS-mutant lung
adenocarcinoma are poorly characterized. We performed an integrative analysis of …
adenocarcinoma are poorly characterized. We performed an integrative analysis of …
Phase II study of the WEE1 inhibitor adavosertib in recurrent uterine serous carcinoma
PURPOSE Uterine serous carcinoma (USC) is a distinct histologic subtype of endometrial
cancer, with molecular characteristics suggesting frequent cell-cycle dysregulation paired …
cancer, with molecular characteristics suggesting frequent cell-cycle dysregulation paired …
Methyl-CpG-binding domain proteins: readers of the epigenome
How DNA methylation is interpreted and influences genome regulation remains largely
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
[HTML][HTML] Novel insights into molecular mechanisms of endometrial diseases
T Golia D'Augè, I Cuccu, G Santangelo, L Muzii… - Biomolecules, 2023 - mdpi.com
Endometrial diseases are the most common gynecological pathologies in Western
Countries. Among these, endometrial cancer (EC) is the most common gynecological …
Countries. Among these, endometrial cancer (EC) is the most common gynecological …
[HTML][HTML] Role of genomic and molecular biology in the modulation of the treatment of endometrial cancer: narrative review and perspectives
I Cuccu, O D'Oria, L Sgamba, E De Angelis… - Healthcare, 2023 - mdpi.com
Endometrial cancer (EC) is one of the most common gynecological malignancies in Western
countries. Traditionally, loco-reginal dissemination and histological characteristics are the …
countries. Traditionally, loco-reginal dissemination and histological characteristics are the …