Ribosomal RNA (rRNA) undergoes post-transcriptional modification of over 200 nucleotides,
predominantly 2′-O-methylation (2′-O-Me). 2′-O-Methylation protects RNA from …

Despite structural differences between the right-handed conformations of A-RNA and B-
DNA, both nucleic acids adopt very similar, left-handed Z-conformations. In contrast to their …

Locked nucleic acids (LNAs) containing one or more 2 '-O, 4 '-C-methylene-linked bicyclic
ribonucleoside monomers possess a number of the prerequisites of an effective antisense …

The aim of this review is to draw a correlation between the structure of the DNA/RNA hybrid
and its properties as a substrate for the RNase H, as well as to point the crucial structural …

More than 100 naturally occurring modified nucleotides have been found in RNA molecules,
in particular in tRNAs. We have determined molecular mechanics force field parameters …

The left-handed Z-conformation of nucleic acids can be adopted by both DNA and RNA
when bound by Zα domains found within a variety of innate immune response proteins. Zα …

When used in nucleic acid duplexes, locked nucleic acid (LNA) and 2′-O-methyl RNA
residues enhance the duplex stabilities, and this makes it possible to create much better …

Studies on hydration are important for better understanding of structure and function of
nucleic acids. We compared the hydration of self‐complementary DNA, RNA and 2′‐O …

The ion atmosphere around nucleic acids is an integral part of their solvated structure.
However, detailed aspects of the ionic distribution are difficult to probe experimentally, and …

An analysis is presented of experimental versus calculated chemical shifts of the non-
exchangeable protons for 28 RNA structures deposited in the Protein Data Bank, covering a …