Speciation, the evolution of reproductive isolation among populations, is continuous,
complex, and involves multiple, interacting barriers. Until it is complete, the effects of this …

Genomic analysis of many nonmodel species has uncovered an incredible diversity of sex
chromosome systems, making it possible to empirically test the rich body of evolutionary …

INTRODUCTION Diversity in the sequence of the human genome, arising from
recombinations and mutations, is fundamental to human evolution and human diversity …

Abstract The 1000 Genomes Project aims to provide a deep characterisation of human
genome sequence variation as a foundation for investigating the relationship between …

During meiosis, a programmed induction of DNA double-strand breaks (DSBs) leads to the
exchange of genetic material between homologous chromosomes. These exchanges …

Meiotic recombination involves the formation and repair of programmed DNA double-strand
breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent …

Sexual reproduction is a fundamental aspect of life. It is defined by the occurrence of meiosis
and the fusion of two gametes of different sexes or mating types. Sex-determination …

Detecting genetic variants that are highly divergent from a reference sequence remains a
major challenge in genome sequencing. We introduce de novo assembly algorithms using …

BACKGROUND Male infertility affects> 20 million men worldwide and represents a major
health concern. Although multifactorial, male infertility has a strong genetic basis which has …

Examining complete gene knockouts within a viable organism can inform on gene function.
We sequenced the exomes of 3222 British adults of Pakistani heritage with high parental …