The blood-brain barrier (BBB) constitutes a microvascular network responsible for excluding
most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the …

Nanoparticle-based therapeutics and diagnostics are commonly referred to as
nanomedicine and may significantly impact the future of healthcare. However, the clinical …

Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to
environmental and developmental changes. One way in which organelles communicate and …

Cationic liposomes (CLs) have been regarded as the most promising gene delivery vectors
for decades with the advantages of excellent biodegradability, biocompatibility, and high …

Cellular internalization of inorganic, lipidic and polymeric nanoparticles is of great
significance in the quest to develop effective formulations for the treatment of high morbidity …

Extracellular vesicles (EVs) are heterogamous lipid bilayer-enclosed membranous
structures secreted by cells. They are comprised of apoptotic bodies, microvesicles, and …

Axons extend for tremendously long distances from the neuronal soma and make use of
localized mRNA translation to rapidly respond to different extracellular stimuli and …

Nanomedical research necessarily involves the study of the interactions between
nanoparticulates and the biological environment. Transmission electron microscopy has …

Highlights•Transcytosis is actively suppressed in CNS endothelial cells for barrier
integrity.•Transcytosis is dynamically regulated during development and …

Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor
tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in …