Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Bcl-2-associated X protein (BAX) is a critical executioner of mitochondrial regulated cell
death through its lethal activity of permeabilizing the mitochondrial outer membrane (MOM) …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair
enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid-based …

Proteins of the B-cell lymphoma-2 (BCL-2) family control the intrinsic apoptosis pathway.
The pro-apoptotic BCL-2 proteins BAX and BAK can commit a cell to its programmed death …

Recent discoveries are redefining our view of cellular senescence as a trigger of tissue
remodelling that acts during normal embryonic development and upon tissue damage. To …

Stress induced by accumulation of misfolded proteins in the endoplasmic reticulum is
observed in many physiological and pathological conditions. To cope with endoplasmic …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …