Despite decades of bile acid research, diverse biological roles for bile acids have been
discovered recently due to developments in understanding the human microbiota. As …

Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …

Non-alcoholic fatty liver disease (NAFLD) is regarded as a pandemic that affects about a
quarter of the global population. Recently, host-gut microbiota metabolic interactions have …

In the past decade, an exciting realization has been that diverse liver diseases—ranging
from nonalcoholic steatohepatitis, alcoholic steatohepatitis and cirrhosis to hepatocellular …

Emerging evidence points to a strong association between the gut microbiota and the risk,
development and progression of gastrointestinal cancers such as colorectal cancer (CRC) …

The gut–liver axis plays a pivotal role in the pathogenesis of nonalcoholic fatty liver disease
(NAFLD), which is the third leading cause of hepatocellular carcinoma (HCC) worldwide …

The primary bile acids (BAs) are synthetized from cholesterol in the liver, conjugated to
glycine or taurine to increase their solubility, secreted into bile, concentrated in the …

The genus of Parasutterella has been defined as a core component of the human and
mouse gut microbiota, and has been correlated with various health outcomes. However, like …

Although obesity occurs in most of the patients with type 2 diabetes (T2D), a fraction of
patients with T2D are underweight or have normal weight. Several studies have linked the …

Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. The lack of
effective biomarkers for the early detection of HCC results in unsatisfactory curative …