JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
DM Schwartz, Y Kanno, A Villarino, M Ward… - Nature reviews Drug …, 2017 - nature.com
The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …
[HTML][HTML] Artificial intelligence for COVID-19 drug discovery and vaccine development
SARS-COV-2 has roused the scientific community with a call to action to combat the growing
pandemic. At the time of this writing, there are as yet no novel antiviral agents or approved …
pandemic. At the time of this writing, there are as yet no novel antiviral agents or approved …
Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality
C Zhang, Z Wu, JW Li, H Zhao, GQ Wang - International journal of …, 2020 - Elsevier
Since December 2019, a viral pneumonia, named coronavirus disease 2019 (COVID-19),
from Wuhan, China, has swept the world. Although the case fatality rate is not high, the …
from Wuhan, China, has swept the world. Although the case fatality rate is not high, the …
[HTML][HTML] JAK–STAT signaling as a target for inflammatory and autoimmune diseases: current and future prospects
The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …
[HTML][HTML] SARS-CoV-2 and COVID-19: Is interleukin-6 (IL-6) the 'culprit lesion'of ARDS onset? What is there besides Tocilizumab? SGP130Fc
G Magro - Cytokine: X, 2020 - Elsevier
Since the outbreak of COVID-19 many studies have been published showing possible
therapies, here the author discusses the end of stage disease related drugs, like …
therapies, here the author discusses the end of stage disease related drugs, like …
[HTML][HTML] Voluntary running suppresses tumor growth through epinephrine-and IL-6-dependent NK cell mobilization and redistribution
L Pedersen, M Idorn, GH Olofsson, B Lauenborg… - Cell metabolism, 2016 - cell.com
Regular exercise reduces the risk of cancer and disease recurrence. Yet the mechanisms
behind this protection remain to be elucidated. In this study, tumor-bearing mice randomized …
behind this protection remain to be elucidated. In this study, tumor-bearing mice randomized …
Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases
Cytokines are major drivers of autoimmunity, and biologic agents targeting cytokines have
revolutionized the treatment of immune-mediated diseases. Despite the effectiveness of …
revolutionized the treatment of immune-mediated diseases. Despite the effectiveness of …
[HTML][HTML] Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19
RK Thimmulappa, KK Mudnakudu-Nagaraju… - Heliyon, 2021 - cell.com
Abstract Coronavirus disease-19 (COVID-19), a devastating respiratory illness caused by
SARS-associated coronavirus-2 (SARS-CoV-2), has already affected over 64 million people …
SARS-associated coronavirus-2 (SARS-CoV-2), has already affected over 64 million people …
Interleukin-6 as potential mediator of long-term neuropsychiatric symptoms of COVID-19
The majority of COVID-19 survivors experience long-term neuropsychiatric symptoms such
as fatigue, sleeping difficulties, depression and anxiety. We propose that neuroimmune …
as fatigue, sleeping difficulties, depression and anxiety. We propose that neuroimmune …
Interleukin-6 and its receptors: a highly regulated and dynamic system
J Wolf, S Rose-John, C Garbers - Cytokine, 2014 - Elsevier
Abstract Interleukin-6 (IL-6) is a multifunctional cytokine with well-defined pro-and anti-
inflammatory properties. Although only small amounts in the picogram range can be …
inflammatory properties. Although only small amounts in the picogram range can be …