Protein tyrosine kinase (PTK) is one of the major signaling enzymes in the process of cell
signal transduction, which catalyzes the transfer of ATP-γ-phosphate to the tyrosine residues …

The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …

The physiological Src proto-oncogene is a protein-tyrosine kinase that plays key roles in cell
growth, division, migration, and survival signaling pathways. From the N-to C-terminus, Src …

The tauopathies constitute a group of diseases that have Tau inclusions in neurons or glia
as their common denominator. In this review, we describe the biochemical and histological …

Phosphorylation is a reversible post-translational modification regulated by phosphorylase
and dephosphorylase to mediate important cellular events. Src homology-2-containing …

Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …

Src family kinases (SFKs) play a central role in mediating the rapid response of platelets to
vascular injury. They transmit activation signals from a diverse repertoire of platelet surface …

Unregulated activation of Src kinases leads to aberrant signalling, uncontrolled growth and
differentiation of cancerous cells. Reaching a complete mechanistic understanding of large …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

As a cornerstone of the innate immune response, neutrophils are the archetypical
phagocytic cell; they actively seek out, ingest, and destroy pathogenic microorganisms. To …