Necrotizing granulomas, exacerbating pathogenesis and neutrophil influx at the site of
infection are hallmarks of active pulmonary tuberculosis (TB) in humans. The role of …

The granuloma is the hallmark of tuberculosis and simultaneously signifies acquisition of an
infection and induction of a host immune response. But who benefits more from the …

Mycobacterium tuberculosis infects two billion people across the globe, and results in 8–9
million new tuberculosis (TB) cases and 1–1.5 million deaths each year. Most patients have …

T cell maturation and activation depend upon T cell receptor (TCR) interactions with a wide
variety of antigenic peptides displayed in a given major histocompatibility complex (MHC) …

Host genetics plays an important role in determining the outcome of Mycobacterium
tuberculosis infection. We previously found that Collaborative Cross (CC) mouse strains …

During tuberculosis (TB) infection, B-lymphocytes migrate to the lungs and form B-cell
follicles (BCFs) in the vicinity of TB granulomata. B-cell-lacking mice display enhanced …

Small non-coding RNAs play a significant role in bacterial adaptation to changing
environmental conditions. We investigated the dynamics of expression of MTS1338, a small …

The journey from phenotypic observation to causal genetic mechanism is a long and
challenging road. For pathogens like Mycobacterium tuberculosis (Mtb), which causes …

Introduction To dissect the role of the part of the H2 complex comprised of the MHC-II genes
in the control of tuberculosis (TB) infection, we previously established a panel of …

Mycobacterium tuberculosis (Mtb) remains a major threat worldwide, although only a fraction
of infected individuals develops tuberculosis (TB). TB susceptibility is shaped by multiple …