▪ Abstract The importance of reactive metabolites in the pathogenesis of drug-induced
toxicity has been a focus of research interest since pioneering investigations in the 1950s …

The critical step in the development of novel approaches to prevent disease is the
translation of laboratory concepts to clinically useful interventions. The expanding database …

Drugs are generally converted to biologically inactive forms and eliminated from the body,
principally by hepatic metabolism. However, certain drugs undergo biotransformation to …

Tamoxifen is an anti-oestrogenic drug widely used for adjuvant therapy of breast cancer. Its
use has caused an increased incidence of endometrial cancer and it is also a potent …

The ability of a compound to cause adverse effects to the liver is one of the most common
reasons for drug development failures and the withdrawal of drugs from the market. Such …

Lamotrigine [3, 5-diamino-6-(2, 3-dichlorophenyl)-1, 2, 4-triazine] is an antiepileptic drug
associated with hypersensitivity reactions which are thought to be an immunological …

Synthetic selective modulators of the estrogen receptors (SERMs) have shown to protect
neurons and glial cells against toxic insults. Among the most relevant beneficial effects …

This study investigates which CYP forms are responsible for the conversion of tamoxifen to
its putative active metabolite α-hydroxytamoxifen and irreversible binding to DNA. We have …

The anti-oestrogen tamoxifen, which is widely used as adjuvant therapy for breast cancer, is
undergoing evaluation as a chemopreventive agent in women at increased risk of …

The antiestrogen tamoxifen is widely used in the adjuvant therapy of breast cancers in
women and helps to prevent the occurrence of breast tumors in healthy women. However …