Metformin is the first-line drug treatment for type 2 diabetes. Globally, over 100 million
patients are prescribed this drug annually. Metformin was discovered before the era of target …

Type 2 diabetes has rapidly emerged as a global health crisis. Because population-level
genetic changes take many generations to occur, this epidemic is almost certainly primarily …

Importance Metformin, a biguanide commonly used to treat type 2 diabetes, has been
associated with potential beneficial effects across breast cancer subtypes in observational …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its
mechanism of action remains unclear. Here the Metformin Genetics (MetGen) Consortium …

Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global
epidemic. In order to achieve optimal glucose control, it is often necessary to rely on …

Diabetes mellitus affects approximately 382 million individuals worldwide and is a leading
cause of morbidity and mortality. Over 40 and nearly 80 genetic loci influencing susceptibility …

This review mainly focuses on metformin, and considers oral antidiabetic therapy in kidney
transplant patients and the potential benefits and risks of antidiabetic agents other than …

The incidence of type 2 diabetes (T2D) and its costs to the health care system continue to
rise. Despite the availability of at least 10 drug classes for the treatment of T2D, metformin …

The prevalence of diabetes worldwide has been steadily increasing over the past 20 years.
In 1997 it was estimated to be 124 million, 1 in 2015 it was estimated to be 415 million …